颈动脉粥样硬化的危险因素：库奥皮奥缺血性心脏病危险因素研究。
Risk factors for carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study.
作者信息
Salonen J T, Seppänen K, Rauramaa R, Salonen R
机构信息
Department of Community Health and General Practice, University of Kuopio, Finland.
出版信息
Ann Med. 1989 Jun;21(3):227-9. doi: 10.3109/07853898909149939.
We assessed the severity of carotid atherosclerosis in 412 men from eastern Finland aged 42, 48, 54 or 60 years at examination with B-mode ultrasonography in 1987 in the Kuopi ischaemic Heart Disease Risk Factor Study (KIHD). Thirty-seven per cent of participants had intimal-medial thickening, 10% had plaques and 2% had stenosis. Age (P less than 0.001), cigarette-years (P less than 0.001), serum LDL cholesterol (P = 0.005), low income (P = 0.020) and low alcohol consumption (P = 0.048) had significant partial associations with the severity of carotid atherosclerosis. A linear regression model including these variables and plasma fibrinogen (NS) and serum HDL-cholesterol (NS) accounted for 33% of the variation in atherosclerosis severity. Our data provide further evidence on the role of smoking and LDL-cholesterol in atherosclerosis.
在库奥皮缺血性心脏病危险因素研究（KIHD）中，我们于1987年采用B型超声对来自芬兰东部的412名年龄在42、48、54或60岁的男性进行了颈动脉粥样硬化严重程度评估。37%的参与者存在内膜中层增厚，10%有斑块，2%有狭窄。年龄（P<0.001）、吸烟量（以吸烟年数计算，P<0.001）、血清低密度脂蛋白胆固醇（P = 0.005）、低收入（P = 0.020）和低酒精摄入量（P = 0.048）与颈动脉粥样硬化严重程度存在显著的部分关联。包含这些变量以及血浆纤维蛋白原（无显著意义）和血清高密度脂蛋白胆固醇（无显著意义）的线性回归模型解释了动脉粥样硬化严重程度变异的33%。我们的数据为吸烟和低密度脂蛋白胆固醇在动脉粥样硬化中的作用提供了进一步证据。
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