Rowbotham D J, Wyld R, Peacock J E, Duthie D J, Nimmo W S
Department of Anaesthesia, Sheffield University, Medical School.
Br J Anaesth. 1989 Jul;63(1):56-9. doi: 10.1093/bja/63.1.56.
Transdermal fentanyl (n = 22) was compared with placebo (n = 18) in a double-blind study of pain after upper abdominal surgery. All patients also received i.v. morphine on demand for supplementary analgesia. The transdermal systems were applied 2 h before induction of anaesthesia and remained in situ for 24 h. After operation, pain scores were significantly lower and peak expiratory flow rates significantly higher in the transdermal fentanyl group, who demanded significantly less morphine than the control group. Mean plasma fentanyl concentrations at 12 and 24 h were within the therapeutic range (1.5 and 2.0 ng ml-1, respectively).
在一项关于上腹部手术后疼痛的双盲研究中，将透皮芬太尼（n = 22）与安慰剂（n = 18）进行了比较。所有患者还按需静脉注射吗啡以辅助镇痛。在麻醉诱导前2小时应用透皮给药系统，并持续放置24小时。术后，透皮芬太尼组的疼痛评分显著更低，呼气峰值流速显著更高，且该组所需的吗啡量明显少于对照组。12小时和24小时时的血浆芬太尼平均浓度均在治疗范围内（分别为1.5和2.0纳克/毫升）。
