Broome I J, Wright B M, Bower S, Reilly C S
Department of Anaesthesia, Falkirk and District Royal Infirmary.
Anaesthesia. 1995 Apr;50(4):300-3. doi: 10.1111/j.1365-2044.1995.tb04603.x.
In a randomised, placebo-controlled, double-blind study involving 81 patients undergoing total abdominal hysterectomy, the postoperative analgesia provided by transdermal fentanyl given at 25, 50, or 75 micrograms.h-1 for 72 h was compared with a placebo group. The efficacy of the Transdermal Therapeutic System was related to the rate of fentanyl delivery, higher rates being associated with significantly lower visual analogue pain scores (24, 20, 17 and 13, for placebo, 25, 50 and 75 micrograms.h-1 respectively) and reduced patient controlled analgesia morphine requirements (44, 38, 33 and 31 mg respectively). Patients' overall sedation scores were not increased by transdermal fentanyl, but respiratory rates decreased with higher transdermal fentanyl dosage.
在一项涉及81例行全腹子宫切除术患者的随机、安慰剂对照、双盲研究中，将每小时给予25、50或75微克芬太尼持续72小时的透皮芬太尼提供的术后镇痛效果与安慰剂组进行了比较。透皮治疗系统的疗效与芬太尼释放速率有关，较高的释放速率与显著更低的视觉模拟疼痛评分（安慰剂组、每小时25微克组、每小时50微克组和每小时75微克组分别为24、20、17和13）以及减少的患者自控镇痛吗啡需求量（分别为44、38、33和31毫克）相关。透皮芬太尼未增加患者的总体镇静评分，但随着透皮芬太尼剂量增加呼吸频率降低。
