University of Buenos Aires, Argentina.
Clin Biochem. 2012 Oct;45(15):1161-6. doi: 10.1016/j.clinbiochem.2012.04.020. Epub 2012 May 4.
To determine the prevalence and distribution of dyslipidemia among urban children from Buenos Aires (BA) versus Koya Indian from San Antonio de los Cobres (SAC).
Anthropometric measures, blood pressure, Tanner stages, glucose, lipids and insulin were measured. Dyslipidemia was defined by the NCEP (the National Cholesterol Education Program standards) and AHA (American Heart Association) criteria.
The mean ages were 10.6 ± 3.0 of SAC and 9.5 ± 2.0 years of BA children. Of the 603 BA children, 97 (16.1%) were overweight (OW) and 82 (13.6%) obese (OB), and of 330 SAC, 15 (4.5%) were OW and 12 (3.6%) OB (p < 0.01). Twenty six percent SAC vs 2.5% BA children ate ≥ 5 servings/day of fruits and vegetables (p < 0.001), 30% SAC vs 59% BA children watched TV ≥ 2 h/day(p < 0.001), and 8.2% SAC vs 13.1% BA children skipped breakfast (p < 0.001). In separate linear regression models, we found that SAC children had a 1.8 mmol/L (p < 0.001) higher hemoglobin level, a 0.56 mmol/L higher triglyceride level (p<0.001), a 0.15 mmol/L higher total cholesterol level (p=0.001), a 0.19 mmol/L higher LDL-C level (p < 0.001), and a 0.33 mmol/L lower HDL-C level (p < 0.001) than BA children adjusted for confounding factors.
Koya children have a higher risk for dyslipidemia in comparison with BA children, even after controlling for lifestyle behaviors, obesity, age, and sex , suggesting that dyslipidemia could be related to their genetic backgrounds.
比较布宜诺斯艾利斯市（BA）的城市儿童和圣安东尼奥德洛斯科布雷斯（SAC）的科雅印第安儿童的血脂异常患病率和分布情况。
测量了体格测量、血压、Tanner 分期、血糖、血脂和胰岛素。血脂异常按照 NCEP（国家胆固醇教育计划标准）和 AHA（美国心脏协会）标准定义。
SAC 组 603 名儿童的平均年龄为 10.6 ± 3.0 岁，BA 组 330 名儿童的平均年龄为 9.5 ± 2.0 岁。BA 组 603 名儿童中，97 名（16.1%）超重（OW），82 名（13.6%）肥胖（OB）；SAC 组 330 名儿童中，15 名（4.5%）OW，12 名（3.6%）OB（p < 0.01）。与 BA 儿童相比，SAC 儿童食用≥5 份/天水果和蔬菜的比例（26% vs 2.5%，p < 0.001）、每天看电视≥2 小时的比例（30% vs 59%，p < 0.001）和不吃早餐的比例（8.2% vs 13.1%，p < 0.001）均较高。在单独的线性回归模型中，我们发现 SAC 儿童的血红蛋白水平高 1.8mmol/L（p < 0.001），甘油三酯水平高 0.56mmol/L（p<0.001），总胆固醇水平高 0.15mmol/L（p=0.001），LDL-C 水平高 0.19mmol/L（p < 0.001），HDL-C 水平低 0.33mmol/L（p < 0.001），这些差异在调整混杂因素后仍然存在。
即使在控制生活方式行为、肥胖、年龄和性别等因素后，与 BA 儿童相比，Koya 儿童的血脂异常风险更高，这表明血脂异常可能与他们的遗传背景有关。
