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部分乳腺近距离放射治疗对侧乳腺的剂量

Contralateral breast dose from partial breast brachytherapy.

作者信息

Robinson R Cole, Nelson Christopher L, Bloom Elizabeth S, Kisling Kelly D, Mason Bryan E, Fisher Gary D, Kirsner Steven M

机构信息

The University of Texas M.D. Anderson Cancer Center.

出版信息

J Appl Clin Med Phys. 2015 Nov 8;16(6):17–22. doi: 10.1120/jacmp.v16i6.5296.

Abstract

The purpose of this study was to determine the dose to the contralateral breast during accelerated partial breast irradiation (APBI) and to compare it to external beam-published values. Thermoluminescent dosimeter (TLD) packets were used to measure the dose to the most medial aspect of the contralateral breast during APBI simulation, daily quality assurance (QA), and treatment. All patients in this study were treated with a single-entry, multicatheter device for 10 fractions to a total dose of 34 Gy. A mark was placed on the patient's skin on the medial aspect of the opposite breast. Three TLD packets were taped to this mark during the pretreatment simulation. Simulations consisted of an AP and Lateral scout and a limited axial scan encompassing the lumpectomy cavity (miniscan), if rotation was a concern. After the simulation the TLD packets were removed and the patients were moved to the high-dose-rate (HDR) vault where three new TLD packets were taped onto the patients at the skin mark. Treatment was administered with a Nucletron HDR afterloader using Iridium-192 as the treatment source. Post-treatment, TLDs were read (along with the simulation and QA TLD and a set of standards exposed to a known dose of 6 MV photons). Measurements indicate an average total dose to the contralateral breast of 70 cGy for outer quadrant implants and 181 cGy for inner quadrant implants. Compared to external beam breast tangents, these results point to less dose being delivered to the contralateral breast when using APBI.

摘要

本研究的目的是确定加速部分乳腺照射(APBI)期间对侧乳腺所接受的剂量,并将其与外照射公布的值进行比较。热释光剂量计(TLD)包用于测量APBI模拟、每日质量保证(QA)和治疗期间对侧乳腺最内侧的剂量。本研究中的所有患者均使用单入口多导管装置进行10次分割照射,总剂量为34 Gy。在患者对侧乳腺内侧的皮肤上做一个标记。在治疗前模拟期间,将三个TLD包粘贴在这个标记上。模拟包括前后位和侧位定位像以及如果需要旋转则进行一次包括乳房切除腔的有限轴向扫描(微扫描)。模拟结束后,取下TLD包,将患者转移到高剂量率(HDR)治疗室,在皮肤标记处将三个新的TLD包粘贴到患者身上。使用铱-192作为治疗源,通过Nucletron HDR后装治疗机进行治疗。治疗后,读取TLD(连同模拟和QA TLD以及一组接受已知剂量6 MV光子照射的标准品)。测量结果表明,外象限植入时对侧乳腺的平均总剂量为70 cGy,内象限植入时为181 cGy。与外照射乳腺切线野相比,这些结果表明使用APBI时对侧乳腺所接受的剂量较少。

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