Kondrashova M N
Biofizika. 1989 May-Jun;34(3):450-8.
Taking into account structural and functional organization of mitochondrial processes it has been shown that at active work there functions in mitochondria an accelerated mechanism of succinic acid formation via coupling of glutamate-oxalacetate transaminase and alpha-ketoglutaratdehydrogenase. This way is closed up into a cycle with the participation of cytosol transaminases which support influx of glutamate, pyruvate and malic acid into mitochondria. When provision of the mitochondria with the substrate proceeds along the transaminase pathway the initial slow region of the tricarboxylic acid cycle is omitted. Thus at active work a faster course is selected. It permits realization of the advantages of succinate dehydrogenase high activity and of oxidation efficiency of succinic acid generated in mitochondria which is essentially higher than that under oxidation of succinic acid and even more of other substrates of the tricarboxylic acid cycle.
考虑到线粒体过程的结构和功能组织，研究表明，在活跃工作时，线粒体中存在一种通过谷氨酸-草酰乙酸转氨酶和α-酮戊二酸脱氢酶偶联形成琥珀酸的加速机制。该途径通过胞质溶胶转氨酶的参与形成一个循环，这些转氨酶支持谷氨酸、丙酮酸和苹果酸流入线粒体。当线粒体通过转氨酶途径获取底物时，三羧酸循环最初的缓慢阶段被省略。因此，在活跃工作时选择了更快的进程。这使得琥珀酸脱氢酶的高活性以及线粒体中生成的琥珀酸的氧化效率的优势得以实现，其本质上高于琥珀酸氧化时的效率，甚至高于三羧酸循环中其他底物氧化时的效率。
