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子宫腺肌病的保守性手术治疗以提高生育能力:存在争议的价值、适应证、并发症及妊娠结局。

Conservative surgical treatment of adenomyosis to improve fertility: Controversial values, indications, complications, and pregnancy outcomes.

作者信息

Tsui Kuan-Hao, Lee Fa-Kung, Seow Kok-Min, Chang Wei-Chun, Wang Jia-Wei, Chen Shee-Uan, Chao Hsiang-Tai, Yen Min-Shyen, Wang Peng-Hui

机构信息

Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung County, Taiwan.

Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.

出版信息

Taiwan J Obstet Gynecol. 2015 Dec;54(6):635-40. doi: 10.1016/j.tjog.2015.05.003.

Abstract

Uterine adenomyosis was first reported in the 19(th) century and early 20(th) century; von Rokitansky described it in 1860. Since then, the general clinical, pathological, and radiologic findings and potentially useful management methods have been reviewed in many studies. Some authors commented that conservative surgical treatment is impracticable as it is not possible to isolate the adenomyotic tissue adequately; therefore, the authors suggested that hysterectomy is the only rational and complete procedure. There is more evidence supporting the advantages of conservative uterine-sparing surgery in providing not only more effective symptom relief, but also longer durable symptom control for symptomatic women with uterine adenomyosis, because the main problem secondary to uterine adenomyosis, dysmenorrhea, can be improved significantly, up to 80%. Menorrhea was also improved in more than two-thirds of patients after type I uterine-sparing surgery, and half of the patients saw benefit in symptom control after type II conservative uterine-sparing surgery. In addition, there was no negative impact on reproductive performance after conservative uterine-sparing surgery, and in fact, reproductive performance seemed to be improved compared with that after medical treatment-not only was there a higher cumulative pregnancy rate, but also a higher cumulative final successful delivery rate. However, there is no doubt that the data supporting the above-mentioned benefits for symptomatic women with uterine adenomyosis after conservative uterine-sparing surgery are limited, suggesting that the benefit may be moderate. In fact, one of the main indications for surgery is temporary pain relief in women seeking spontaneous conception. However, the effect of surgery on pain is usually only temporarily satisfactory, and the risk of complications varies according to the type of lesion extirpated. In light of this, an extensive review of this topic addressing conservative surgical treatment for adenomyosis to improve fertility, including controversial values, indications, complications, and pregnancy outcomes, might be very important, and might help physicians in managing these patients in the future.

摘要

子宫腺肌病最早在19世纪和20世纪初被报道;冯·罗基坦斯基在1860年对其进行了描述。从那时起,许多研究对其一般临床、病理和放射学表现以及可能有用的治疗方法进行了综述。一些作者认为保守性手术治疗不可行,因为无法充分分离腺肌病组织;因此,这些作者建议子宫切除术是唯一合理且彻底的手术方式。有更多证据支持保留子宫的保守性手术的优势,它不仅能更有效地缓解症状,还能为有症状的子宫腺肌病女性提供更持久的症状控制,因为子宫腺肌病的主要继发问题痛经可得到显著改善,改善率高达80%。超过三分之二的患者在I型保留子宫手术后月经过多情况得到改善,一半的患者在II型保留子宫保守性手术后症状控制方面获益。此外,保留子宫的保守性手术对生殖性能没有负面影响,事实上,与药物治疗后相比,生殖性能似乎有所改善——不仅累积妊娠率更高,累积最终成功分娩率也更高。然而,毫无疑问,支持保留子宫的保守性手术对有症状的子宫腺肌病女性有上述益处的数据有限,这表明这种益处可能是中等程度的。实际上,手术的主要指征之一是为寻求自然受孕的女性暂时缓解疼痛。然而,手术对疼痛的效果通常只是暂时令人满意,并发症风险因切除病变的类型而异。有鉴于此,对这个主题进行广泛综述,探讨腺肌病的保守性手术治疗以提高生育能力,包括有争议的价值、指征、并发症和妊娠结局,可能非常重要,并且可能有助于医生在未来管理这些患者。

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