Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Chem Commun (Camb). 2016 Feb 4;52(10):2153-6. doi: 10.1039/c5cc08873a.
Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by K(+)-stabilized G-quadruplex units. The binding of hemin to the second system yields a bifunctional DNA scaffold with alternate catalytic functions.
在超分子 β-环糊精/金刚烷寡核苷酸支架存在的情况下，展示了对 m-叔丁基苯乙酸酯的可切换 β-环糊精诱导水解。在一个体系中，β-环糊精功能化核酸与金刚烷核酸之间的双链导致可切换催化体系。在第二个体系中，通过 K(+)稳定的 G-四联体单元协同生成β-CD/金刚烷二聚体。血红素与第二个体系的结合产生具有交替催化功能的双功能 DNA 支架。
