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基于 DNA 的结构动态网络的光诱导可逆重构:在可切换催化中的应用。

Light-Induced Reversible Reconfiguration of DNA-Based Constitutional Dynamic Networks: Application to Switchable Catalysis.

机构信息

Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Key Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

出版信息

Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8105-8109. doi: 10.1002/anie.201803371. Epub 2018 May 25.

Abstract

The light-induced reversible and cyclic reconfiguration of constitutional dynamic networks, consisting of supramolecular nucleic acid structures as constituents and a photoisomerizable trans/cis-azobenzene-functionalized nucleic acid as the trigger is demonstrated. In addition, the cyclic photochemical reconfiguration of the constitutional dynamic networks guides the switchable on/off operation of an emerging hemin/G-quadruplex DNAzyme.

摘要

本文展示了由超分子核酸结构作为组成部分和光致变色反式/顺式-偶氮苯功能化核酸作为触发物的组成的结构动态网络的光诱导可逆和循环重构。此外,结构动态网络的循环光化学重构指导了新兴血红素/G-四链体 DNA 酶的开关操作。

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