Pessoa Larissa, Galvão Virgilio, Damante Carla, Sant'Ana Adriana Campos Passanezi
Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Catholic University of Brasília, Brasília, Brazil.
BMJ Case Rep. 2015 Dec 23;2015:bcr2015212276. doi: 10.1136/bcr-2015-212276.
Black-pigmented bacteria (BPB) are Gram-negative anaerobic, non-motile, proteolytic rods strongly implicated in the pathogenesis of periodontal disease. Although pigments are produced in vitro, black pigmentation is rarely found clinically. However, it may compromise aesthetics and contribute to gingival inflammation. The aim of this report is to describe a clinical case of a 10-year-old boy showing black pigmentation covering all teeth and to propose an alternative therapy for removal of black pigmentation, based on photodynamic therapy (PDT). In order to perform microbiological analysis, plaque samples were collected before and after PDT, and analysed by real-time-PCR (RT-PCR). The results showed a significant reduction in BPB levels after therapy, along with clinical evidence of absence of black pigmentation and reduction in gingival bleeding, although the plaque index remained unaltered. This case showed that PDT is effective for eliminating black pigmentation caused by BPB, without recurrence during a follow-up period of 7 months.
黑色色素细菌（BPB）是革兰氏阴性厌氧菌，无运动性，为蛋白水解杆菌，与牙周病的发病机制密切相关。虽然色素可在体外产生，但临床上很少发现黑色色素沉着。然而，它可能影响美观并导致牙龈炎症。本报告的目的是描述一名10岁男孩出现覆盖所有牙齿的黑色色素沉着的临床病例，并提出一种基于光动力疗法（PDT）去除黑色色素沉着的替代疗法。为了进行微生物分析，在PDT前后收集菌斑样本，并通过实时聚合酶链反应（RT-PCR）进行分析。结果显示，治疗后BPB水平显著降低，同时有临床证据表明黑色色素沉着消失且牙龈出血减少，尽管菌斑指数保持不变。该病例表明，PDT对于消除由BPB引起的黑色色素沉着有效，在7个月的随访期内无复发。
