Holmes Laurens, LaHurd Alex, Wasson Emily, McClarin Lavisha, Dabney Kirk
Nemours/A.I. duPont Children's Hospital, Nemours Office of Health Equity & Inclusion, 2200 Concord Pike, 8th Floor, Wilmington, DE 19803, USA.
Biological Sciences Department, University of Delaware, Newark, DE 19711, USA.
Int J Environ Res Public Health. 2015 Dec 23;13(1):ijerph13010019. doi: 10.3390/ijerph13010019.
Total cholesterol (TC) directly correlates with overweight/obesity, but it remains unclear if this association varies by race and ethnicity. We assessed the association as well as the racial/ethnic heterogeneity in this relationship. Data on 63,863 children were assessed using electronic medical records between 2010 and 2011. A cross-sectional design was utilized with log-binomial regression model and chi-squared statistic to examine the data. Overall, abnormal total cholesterol (ATC) was 7.5% (4812). Significant racial variability in ATC was observed: Black/African American (AA) (7.4%), White (7.0%), Asian (5.1%) and some other race (SOR) children (11.3%), χ² (5) = 141.5, p < 0.0001. Black/AA (34.7%) and SOR children (41.2%) were predominantly overweight/obese, unlike the Asian children, (25.8%), χ² (5) = 324.6, p < 0.0001. The BMI percentile was highest among SOR (69.0 ± 28.6) and Black/AA children (65.2 ± 29.1), but lowest among Asian children (55.7 ± 31.5). A significant racial variability was also observed in weight, with the highest mean among Black/AA children (36.8kg ± 23.0) and the lowest among Asian children (28.7kg ± 16.8), f = 7.2, p < 0.001. Relative to normal TC, children with ATC were 2.6 times as likely to have abnormal BMI, relative risk (RR) =2.60, 99% CI, 2.54-2.68). Compared to non-Hispanic (RR = 2.62, 99% CI, 2.54-2.69), the risk was lower among Hispanics (RR = 2.34, 99%, 2.21-2.48). Among children with ATC, risk for abnormal BMI was highest among Asians, adjusted RR = 2.91, 99% CI, 2.34-3.62), intermediate among AA (ARR = 2.68, 99% CI, 2.59-2.77), but lowest among Whites (ARR = 2.40, 99% CI, 2.39-2.64), and SOR (ARR = 2.33, 99% CI, 2.19-2.50). In a large sample of children, total cholesterol directly correlates with BMI, with an observed racial and ethnic heterogeneity.
总胆固醇（TC）与超重/肥胖直接相关，但这种关联是否因种族和民族而异尚不清楚。我们评估了这种关联以及这种关系中的种族/民族异质性。使用2010年至2011年期间的电子病历对63863名儿童的数据进行了评估。采用横断面设计，使用对数二项回归模型和卡方统计量来检查数据。总体而言，异常总胆固醇（ATC）为7.5%（4812例）。观察到ATC存在显著的种族差异：黑人/非裔美国人（AA）（7.4%）、白人（7.0%）、亚洲人（5.1%）和其他一些种族（SOR）儿童（11.3%），χ²（5）=141.5，p<0.0001。与亚洲儿童（25.8%）不同，黑人/AA（34.7%）和SOR儿童（41.2%）主要超重/肥胖，χ²（5）=324.6，p<0.0001。BMI百分位数在SOR（69.0±28.6）和黑人/AA儿童（65.2±29.1）中最高，但在亚洲儿童（55.7±31.5）中最低。体重也存在显著的种族差异，黑人/AA儿童的平均体重最高（36.8kg±23.0），亚洲儿童最低（28.7kg±16.8），F=7.2，p<0.001。与正常TC相比，ATC儿童的BMI异常可能性是正常儿童的2.6倍，相对风险（RR）=2.60，%99置信区间，2.54-2.68）。与非西班牙裔（RR=2.62，99%置信区间，2.54-2.69）相比，西班牙裔的风险较低（RR=2.34，99%，2.21-2.48）。在ATC儿童中，亚洲人的BMI异常风险最高，调整后RR=2.91，99%置信区间，2.34-3.62），AA儿童居中（ARR=2.68，99%置信区间，2.59-2.77），但白人（ARR=2.40，99%置信区间，2.39-2.64）和SOR儿童最低（ARR=2.33，99%置信区间，2.19-2.50）。在一大群儿童样本中，总胆固醇与BMI直接相关，存在种族和民族异质性。
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