中国社区人群入睡时间与心血管代谢生物标志物的关系：一项横断面研究。
The relationship between sleep onset time and cardiometabolic biomarkers in Chinese communities: a cross-sectional study.
机构信息
School of Public Health and Management, Ningxia Medical University, Yinchuan, 750004, China.
Surgical Laboratory of General Hospital, Ningxia Medical University, Yinchuan, 750004, China.
出版信息
BMC Public Health. 2020 Mar 20;20(1):374. doi: 10.1186/s12889-020-08516-9.
BACKGROUND
Late sleep onset time (SOT) is a common social phenomenon in modern society, and it was associated with a higher risk of obesity. However, the literature gap exists about the SOT and cardiometabolic biomarkers which closely associated with obesity. The present study aimed to explore the association of SOT with cardiometabolic biomarkers in Chinese communities.
METHODS
A cross-sectional study enrolled a total of 2418 participants was conducted in Ningxia province of China. The cardiometabolic biomarkers included triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein and fasting plasma glucose were measured quantitatively using the standard method. The SOT and sleep duration were acquired by a self-report questionnaire. The multiple mixed-effect linear regression model was employed to examine the association.
RESULTS
Binary analysis found an inverse association of SOT with high-density lipoprotein (β = - 0.05, 95%CI: - 0.06, - 0.03), with 1 h delayed in SOT the high-density lipoprotein decreased 0.05 mmol/L. After controlling for demographic variables, health-related behaviors, and physical health covariates, late SOT was associated with a higher level of triglyceride (β = 0.12, 95%CI: 0.06, 0.18), a higher level of low-density lipoprotein (β = 0.06, 95% CI: 0.02, 0.09), and a lower level of high-density lipoprotein (β = - 0.05, 95% CI: - 0.06, - 0.03). when stratified by sleep duration (less than eight hours vs. eight and longer hours), a positive association between SOT and LDL (β = 0.08, 95% CI: 0.04, 0.12) was found among participants with sleep duration eight hours and longer.
CONCLUSION
Late sleep onset time with the negative effect on the cardiometabolic biomarkers, and individuals with late SOT coupled with longer sleep duration may take risk of a higher level of low-density lipoprotein which in turn lead to increase the risk of cardiovascular disease.
背景
晚睡晚起是现代社会的一种常见现象，与肥胖的风险增加有关。然而，关于晚睡晚起与肥胖密切相关的心脏代谢生物标志物的文献仍存在空白。本研究旨在探讨中国社区晚睡晚起与心脏代谢生物标志物的关系。
方法
采用横断面研究，在中国宁夏回族自治区共纳入 2418 名参与者。心脏代谢生物标志物包括甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白和空腹血糖，采用标准方法进行定量检测。晚睡晚起时间和睡眠时间通过自报问卷获得。采用多混合效应线性回归模型进行分析。
结果
二分类分析发现，晚睡晚起与高密度脂蛋白呈负相关（β=-0.05，95%CI：-0.06，-0.03），晚睡晚起 1 小时，高密度脂蛋白降低 0.05mmol/L。控制人口统计学变量、与健康相关的行为和身体健康相关因素后，晚睡晚起与甘油三酯水平升高（β=0.12，95%CI：0.06，0.18）、低密度脂蛋白水平升高（β=0.06，95%CI：0.02，0.09）和高密度脂蛋白水平降低（β=-0.05，95%CI：-0.06，-0.03）有关。按睡眠时间（<8 小时与≥8 小时）分层，在睡眠时间≥8 小时的参与者中，晚睡晚起与 LDL 呈正相关（β=0.08，95%CI：0.04，0.12）。
结论
晚睡晚起对心脏代谢生物标志物有负面影响，晚睡晚起且睡眠时间较长的个体可能存在低密度脂蛋白水平升高的风险，进而增加心血管疾病的风险。
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