Oveisgharan Shahram, Hachinski Vladimir
RUSH Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA Neurology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada.
Am J Alzheimers Dis Other Demen. 2016 Nov;31(7):545-550. doi: 10.1177/1533317515619480. Epub 2015 Dec 24.
We hypothesized that neuropsychological tests could help in identifying preclinical stages of vascular cognitive impairment, when aspirin use might be associated with lower dementia incidence.
We used data of Canadian Study of Health and Aging (CSHA) which was a longitudinal study of Canadians older than 65 years and was done in 3 waves, 1991 to 1992 (CSHA-1), 1996 to 1997 (CSHA-2), and 2001 to 2002.
CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease. Salicylates use was associated with lower incident dementia among normal cognition CSHA-1 participants who had low scores in copying pentagons and writing subtests after controlling for age, sex, education, and vascular risk factors (odds ratio = 0.25, 95% confidence interval: 0.073-0.86, P = .028).
Two simple neuropsychological tests might help in identifying preclinical stages of vascular cognitive impairment, and salicylates use was associated with lower dementia incidence.
我们推测，神经心理学测试有助于识别血管性认知障碍的临床前期阶段，此时使用阿司匹林可能与较低的痴呆发病率相关。
我们使用了加拿大健康与老龄化研究（CSHA）的数据，该研究是一项针对65岁以上加拿大人的纵向研究，分三个阶段进行，分别为1991年至1992年（CSHA-1）、1996年至1997年（CSHA-2）以及2001年至2002年。
与可能患有阿尔茨海默病的参与者相比，患有血管性痴呆的CSHA-1参与者在复制五边形和改良简易精神状态检查表的书写子测试中表现更差。在控制了年龄、性别、教育程度和血管危险因素后，在复制五边形和书写子测试中得分较低的正常认知CSHA-1参与者中，使用水杨酸盐与较低的痴呆发病率相关（比值比 = 0.25，95%置信区间：0.073 - 0.86，P = 0.028）。
两项简单的神经心理学测试可能有助于识别血管性认知障碍的临床前期阶段，且使用水杨酸盐与较低的痴呆发病率相关。
