肿瘤中的 TLS：内在之谜。
TLS in Tumors: What Lies Within.
机构信息
INSERM, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; University Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; UPMC University Paris 06, Sorbonne Universités, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France.
INSERM, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; University Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; UPMC University Paris 06, Sorbonne Universités, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France.
出版信息
Trends Immunol. 2016 Jan;37(1):1-2. doi: 10.1016/j.it.2015.12.001. Epub 2015 Dec 17.
The role of tertiary lymphoid structures (TLS) in cancer has recently been illustrated and revisited using mouse models. Joshi et al. describe regulatory T (Treg) cell infiltration and functional heterogeneity of TLS in lung tumors. Finkin et al. report that inflammation-associated TLS serve as niche for tumor progenitor cells, which may lead to recurrence in hepatocellular-carcinoma.
最近，利用小鼠模型，已经阐述和重新研究了三级淋巴结构 (TLS) 在癌症中的作用。Joshi 等人描述了肺肿瘤中调节性 T (Treg) 细胞浸润和 TLS 的功能异质性。Finkin 等人报告说，与炎症相关的 TLS 可作为肿瘤祖细胞的龛位，这可能导致肝细胞癌的复发。
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