Wang Y, Teichtahl A J, Cicuttini F M
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC 3004, Australia.
Osteoarthritis Cartilage. 2016 Jan;24(1):49-57. doi: 10.1016/j.joca.2015.07.027.
This narrative review covers original publications related to imaging in osteoarthritis (OA) published in English between 1 April 2014 and 30 April 2015. Novel lessons relating to imaging are described.
An extensive PubMed database search was performed based on, but not limited to the terms "OA" in combination with "Magnetic resonance imaging (MRI)", "Imaging", "Radiography", "Ultrasound", "Computed tomography (CT)" and "Nuclear medicine" to extract relevant studies. In vitro data and animal studies were excluded. This review focuses on the new developments and observations based on the aforementioned imaging modalities, as well as a 'whole-organ' approach by presenting findings from different tissues (bone, meniscus, synovium, muscle and fat) and joints (hip, lumbar spine and hand).
Over the past year, studies using imagine have made a major contribution to the understanding of the pathogenesis of OA. Significant work has continued at the knee, with MRI now being increasingly used to assess structural endpoints in clinical trials. This offers the exciting opportunity to explore potential disease modifying OA therapies. There has been a clear interest in the role of bone in the pathogenesis of OA. There is now a growing body of literature examining the pathogenesis of OA at the hip, lumbar spine and hand. The future of imaging in OA offers the exciting potential to better understand the disease process across all joints and develop more effective preventive and therapeutic interventions.
本叙述性综述涵盖2014年4月1日至2015年4月30日期间以英文发表的与骨关节炎（OA）影像学相关的原始出版物。描述了与影像学相关的新经验教训。
基于但不限于“OA”与“磁共振成像（MRI）”、“成像”、“放射摄影”、“超声”、“计算机断层扫描（CT）”和“核医学”相结合的术语，在PubMed数据库中进行了广泛搜索，以提取相关研究。排除体外数据和动物研究。本综述重点关注基于上述成像模式的新进展和观察结果，以及通过展示来自不同组织（骨、半月板、滑膜、肌肉和脂肪）和关节（髋、腰椎和手）的发现的“全器官”方法。
在过去一年中，使用影像学的研究对理解OA的发病机制做出了重大贡献。膝关节方面的重要工作仍在继续，MRI现在越来越多地用于评估临床试验中的结构终点。这为探索潜在的疾病修饰性OA疗法提供了令人兴奋的机会。人们对骨在OA发病机制中的作用有了明显的兴趣。现在有越来越多的文献研究髋、腰椎和手部OA的发病机制。OA影像学的未来为更好地理解所有关节的疾病过程以及开发更有效的预防和治疗干预措施提供了令人兴奋的潜力。
