Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria Chondrometrics GmbH, Ainring, Germany.
Division of Rheumatology and University of Arizona Arthritis Center, University of Arizona, Tucson, Arizona, USA.
Ann Rheum Dis. 2014 Jul;73(7):1289-300. doi: 10.1136/annrheumdis-2014-205310. Epub 2014 Apr 12.
The Osteoarthritis Initiative (OAI) is a multicentre, prospective, observational, cohort study of knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to clinical and image data, enabling researchers to examine risk factors/predictors and the natural history of knee OA incidence and progression, and the qualification of imaging and other biomarkers. In this narrative review, we report imaging findings and lessons learned 10 years after enrolment has started. A literature search for full text articles published from the OAI was performed up to 31 December 2013 using Pubmed and the OAI web page. We summarise the rationale, design and imaging protocol of the OAI, and the history of OAI publications. We review studies from early partial, and later full OAI public data releases. The latter are structured by imaging method and tissue, reviewing radiography and then MRI findings on cartilage morphology, cartilage lesions and composition (T2), bone, meniscus, muscle and adipose tissue. Finally, analyses directly comparing findings from MRI and radiography are summarised. Ten years after the first participants were enrolled and first papers published, the OAI has become an invaluable resource to the OA research community. It has fuelled novel methodological approaches of analysing images, and has provided a wealth of information on OA pathophysiology. Continued collection and public release of long-term observations will help imaging measures to gain scientific and regulatory acceptance as 'prognostic' or 'efficacy of intervention' biomarkers, potentially enabling shorter and more efficient clinical trials that can test structure-modifying therapeutic interventions (NCT00080171).
骨关节炎倡议 (OAI) 是一项多中心、前瞻性、观察性、队列研究，研究对象为膝关节骨关节炎 (OA)，于 2004 年开始招募患者。OAI 向公众开放临床和影像数据，使研究人员能够研究膝关节 OA 发病和进展的风险因素/预测因子和自然史，以及影像和其他生物标志物的鉴定。在这篇叙述性综述中，我们报告了开始招募 10 年后的影像发现和经验教训。使用 Pubmed 和 OAI 网页对从 OAI 发表的全文文章进行了文献检索，检索截至 2013 年 12 月 31 日。我们总结了 OAI 的原理、设计和影像方案，以及 OAI 出版物的历史。我们回顾了早期部分和后来完整的 OAI 公共数据发布的研究。后者按影像方法和组织进行分类，先回顾放射学，然后回顾软骨形态、软骨病变和成分 (T2)、骨、半月板、肌肉和脂肪组织的 MRI 发现。最后，总结了直接比较 MRI 和放射学发现的分析。在第一批参与者入组和第一批论文发表 10 年后，OAI 已成为 OA 研究界不可或缺的资源。它激发了分析影像的新方法，并提供了大量关于 OA 病理生理学的信息。持续收集和公开发布长期观察结果将有助于使影像测量作为“预后”或“干预效果”的生物标志物获得科学和监管机构的认可，这可能使结构修饰治疗干预的临床试验更短、更有效（NCT00080171）。
