Cai Chengchen, Zhang Ruojing, Xu Xiaoli, Li Guowen, Gou Haixin
Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China.
Department of Scientific Research, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 200082, P.R. China.
Exp Ther Med. 2021 Jan;21(1):74. doi: 10.3892/etm.2020.9506. Epub 2020 Nov 25.
The present study aimed to explore the diagnostic values of neutrophil-lymphocyte ratio (NLR) and microRNA (miR)-141 in patients with osteoarthritis and their association with the severity of knee osteoarthritis. In total 142 patients with osteoarthritis (the study group) admitted to Shanghai TCM-Integrated Hospital, Shanghai University of TCM from January 2017 to January 2019 and 150 healthy controls (the control group) were enrolled in the present study. NLR and miR-141 in peripheral blood and their diagnostic values for osteoarthritis were compared between the two groups. The two indicators in the study group were significantly increased (P<0.001), and their combined detection had a better diagnostic value for the disease (P<0.001). Moreover, they were closely associated to the progression of the disease and were independent risk factors (P<0.001). To sum up, NLR and miR-141 were significantly increased in the peripheral blood of patients with osteoarthritis. Their combined detection exhibited a good diagnostic value for the disease and may become a potential therapeutic target osteoarthritis in the future.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）和微小RNA（miR）-141在骨关节炎患者中的诊断价值及其与膝关节骨关节炎严重程度的关系。2017年1月至2019年1月期间，上海中医药大学附属上海市中西医结合医院收治的142例骨关节炎患者（研究组）和150例健康对照者（对照组）纳入本研究。比较两组外周血中NLR和miR-141及其对骨关节炎的诊断价值。研究组的这两项指标均显著升高（P<0.001），联合检测对该疾病具有更好的诊断价值（P<0.001）。此外，它们与疾病进展密切相关，是独立危险因素（P<0.001）。综上所述，骨关节炎患者外周血中NLR和miR-141显著升高。它们的联合检测对该疾病具有良好的诊断价值，未来可能成为骨关节炎的潜在治疗靶点。
