视觉线索对海马体方向选择性的因果影响。

Causal Influence of Visual Cues on Hippocampal Directional Selectivity.

机构信息

W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA; Biomedical Engineering Interdepartmental Program, University of California at Los Angeles, Los Angeles, CA 90095, USA.

W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA; Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, CA 90095, USA.

出版信息

Cell. 2016 Jan 14;164(1-2):197-207. doi: 10.1016/j.cell.2015.12.015. Epub 2015 Dec 17.

DOI:10.1016/j.cell.2015.12.015

PMID:26709045

Abstract

Hippocampal neurons show selectivity with respect to visual cues in primates, including humans, but this has never been found in rodents. To address this long-standing discrepancy, we measured hippocampal activity from rodents during real-world random foraging. Surprisingly, ∼ 25% of neurons exhibited significant directional modulation with respect to visual cues. To dissociate the contributions of visual and vestibular cues, we made similar measurements in virtual reality, in which only visual cues were informative. Here, we found significant directional modulation despite the severe loss of vestibular information, challenging prevailing theories of directionality. Changes in the amount of angular information in visual cues induced corresponding changes in head-directional modulation at the neuronal and population levels. Thus, visual cues are sufficient for-and play a predictable, causal role in-generating directionally selective hippocampal responses. These results dissociate hippocampal directional and spatial selectivity and bridge the gap between primate and rodent studies.

摘要

在包括人类在内的灵长类动物中，海马体神经元对视觉线索具有选择性，但在啮齿类动物中从未发现过这种现象。为了解决这一长期存在的差异，我们在真实世界的随机觅食过程中测量了啮齿动物的海马体活动。令人惊讶的是，约 25%的神经元对视觉线索表现出显著的方向调制。为了区分视觉和前庭线索的贡献，我们在虚拟现实中进行了类似的测量，其中只有视觉线索是有信息的。在这里，尽管前庭信息严重缺失，我们仍然发现了显著的方向调制，这挑战了现有的方向理论。视觉线索中角信息的数量变化在神经元和群体水平上引起了相应的头向调制变化。因此，视觉线索足以产生并在方向选择性海马体反应中发挥可预测的因果作用。这些结果分离了海马体的方向和空间选择性，并弥合了灵长类动物和啮齿类动物研究之间的差距。