School of Nursing, Fudan University, 200032, China; Department of Obstetrics, Obstetrics & Gynaecology Hospital of Fudan University, Shanghai 200090, China.
Department of Obstetrics, Obstetrics & Gynaecology Hospital of Fudan University, Shanghai 200090, China.
J Affect Disord. 2021 Mar 1;282:98-103. doi: 10.1016/j.jad.2020.12.129. Epub 2020 Dec 28.
Anxiety is common during pregnancy. The 7-item Generalized Anxiety Disorder scale (GAD-7) is a self-rating scale for detecting anxiety and has been validated in various populations, but it has not been validated in pregnant Chinese women. The objective of this study was to validate the GAD-7 as a screening tool to detect anxiety during pregnancy among Chinese women.
The GAD-7 and the anxiety subscale of the Hospital Anxiety and Depression scale (HADS-A) were administered to 140 pregnant Chinese women to evaluate the Cronbach's alpha and the criterion-related validity. Additionally, a diagnostic study (n=170) was conducted by using the Mini International Neuropsychiatric Interview (MINI) as a gold standard to examine the screening performance of the GAD-7. We calculated the sensitivity, specificity, and area under the curve (AUC) by receiver operating characteristic (ROC) analysis.
Cronbach's alpha for the GAD-7 was 0.84. The Pearson correlation coefficient between GAD-7 and HADS-A scores was 0.66 (P<0.01). At the maximum Youden Index of 0.53, the optimal cutoff score for the GAD-7 among pregnant women was 7, and an AUC of 0.83, a sensitivity of 96.8%, and a specificity of 56.1% were obtained.
The majority of the participants were in the first trimester, and thus, the findings cannot be generalized to all pregnant women.
The GAD-7 is a suitable screening instrument for detecting antenatal anxiety in mainland China. Further validation is warranted in women in different trimesters of pregnancy.
焦虑在怀孕期间很常见。7 项广泛性焦虑障碍量表（GAD-7）是一种用于检测焦虑的自评量表，已在各种人群中得到验证，但尚未在怀孕的中国女性中得到验证。本研究的目的是验证 GAD-7 作为一种筛查工具，用于检测中国女性怀孕期间的焦虑。
对 140 名中国孕妇进行 GAD-7 和医院焦虑抑郁量表（HADS-A）焦虑分量表的评估，以评估 Cronbach's alpha 和效标关联效度。此外，通过使用 Mini 国际神经精神访谈（MINI）作为金标准进行诊断研究（n=170），以检查 GAD-7 的筛查性能。我们通过接受者操作特征（ROC）分析计算灵敏度、特异性和曲线下面积（AUC）。
GAD-7 的 Cronbach's alpha 为 0.84。GAD-7 与 HADS-A 评分之间的 Pearson 相关系数为 0.66（P<0.01）。在最大 Youden 指数为 0.53 时，孕妇 GAD-7 的最佳截断值为 7，AUC 为 0.83，灵敏度为 96.8%，特异性为 56.1%。
大多数参与者处于孕早期，因此，研究结果不能推广到所有孕妇。
GAD-7 是一种适合检测中国大陆产前焦虑的筛查工具。在不同孕期的女性中进一步验证是必要的。
