Kim Youngyo, Je Youjin
Department of food and nutrition, Kyung Hee university, 26, Kyunghee-daero, Dongdaemun-gu, 130-701 Seoul, South Korea.
Department of food and nutrition, Kyung Hee university, 26, Kyunghee-daero, Dongdaemun-gu, 130-701 Seoul, South Korea.
Arch Cardiovasc Dis. 2016 Jan;109(1):39-54. doi: 10.1016/j.acvd.2015.09.005. Epub 2015 Dec 18.
Accumulating evidence supports health benefits of dietary fibre, such as improving lipid profiles, lowering blood pressure and improving insulin sensitivity, but evidence from comprehensive investigation of dietary fibre intake and mortality from cardiovascular disease (CVD) and all cancers is limited.
To quantitatively assess the association between dietary fibre intake and mortality from CVD and all cancers.
We performed a meta-analysis of prospective cohort studies. Eligible studies were identified by searching PubMed and Embase databases for all articles published up to September 2014 and via hand searching. Study-specific estimates adjusting for potential confounders were combined to calculate pooled relative risks (RRs) with 95% confidence intervals (CIs), using a random-effects model.
We found 15 studies that examined the association between dietary fibre and mortality from CVD, coronary heart disease (CHD) and all cancers. The pooled RRs of CVD, CHD and all-cancer mortality for the highest versus lowest category of dietary fibre were 0.77 (95% CI: 0.71-0.84), 0.76 (95% CI: 0.67-0.87) and 0.86 (95% CI: 0.79-0.93), respectively. In a dose-response meta-analysis, the pooled RRs for an increment of 10 g/day in dietary fibre intake were 0.91 (95% CI: 0.88-0.94) for CVD, 0.89 (95% CI: 0.85-0.93) for CHD and 0.94 (95% CI: 0.91-0.97) for all cancers.
Our findings suggest that high dietary fibre intake is associated with a reduced risk of mortality from CVD and all cancers. These results support the current recommendation that high dietary fibre intake should be part of a healthy diet.
越来越多的证据支持膳食纤维对健康有益，比如改善血脂水平、降低血压以及提高胰岛素敏感性，但关于膳食纤维摄入量与心血管疾病（CVD）和所有癌症死亡率之间全面调查的证据有限。
定量评估膳食纤维摄入量与CVD和所有癌症死亡率之间的关联。
我们对前瞻性队列研究进行了荟萃分析。通过检索PubMed和Embase数据库以查找截至2014年9月发表的所有文章，并通过手工检索来确定符合条件的研究。使用随机效应模型，将针对潜在混杂因素进行调整的研究特定估计值合并，以计算合并相对风险（RRs）及95%置信区间（CIs）。
我们发现15项研究探讨了膳食纤维与CVD、冠心病（CHD）和所有癌症死亡率之间的关联。膳食纤维摄入量最高组与最低组相比，CVD、CHD和所有癌症死亡率的合并RRs分别为0.77（95%CI：0.71 - 0.84）、0.76（95%CI：0.67 - 0.87）和0.86（95%CI：0.79 - 0.93）。在剂量反应荟萃分析中，膳食纤维摄入量每增加10克/天，CVD的合并RRs为0.91（95%CI：0.88 - 0.94），CHD为0.89（95%CI：0.85 - 0.93），所有癌症为0.94（95%CI：0.91 - 0.97）。
我们的研究结果表明，高膳食纤维摄入量与降低CVD和所有癌症的死亡风险相关。这些结果支持当前的建议，即高膳食纤维摄入量应成为健康饮食的一部分。
