Khorramdelazad Hossein, Bagheri Vahid, Hassanshahi Gholamhossein, Zeinali Masoud, Vakilian Alireza
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
J Neuroimmunol. 2016 Jan 15;290:70-5. doi: 10.1016/j.jneuroim.2015.11.021. Epub 2015 Nov 24.
The etiology of several autoimmune diseases, including multiple sclerosis (MS) is still not clarified. MS is defined as an autoimmune disease with clinical features of a chronic, inflammatory, and demyelinating autoimmune disorder, which affects the central nervous system. Phases of remission and relapse are the major course of the disease, which could be exacerbated in terms of both severity and duration. As a subfamily of the cytokines, chemokines act as chemoattractants for a wide variety of cells, including immune cells. CXCL12, which is an important member of the CXC subfamily, has been widely explored in the hematopoietic system. In the peripheral immune system, CXCL12/CXCR4 performs pleiotropic functions. CXCL12 is a highly effective chemoattractant for lymphocytes and monocytes but not neutrophils. CXCL12 is present in the cerebrospinal fluid (CSF) of patients with MS and other inflammatory neurological disorders. The aim of this study is to summarize recent findings regarding the relationship between CXCL12 and MS.
包括多发性硬化症（MS）在内的几种自身免疫性疾病的病因仍未明确。MS被定义为一种具有慢性、炎症性和脱髓鞘性自身免疫性疾病临床特征的自身免疫性疾病，它会影响中枢神经系统。缓解期和复发期是该疾病的主要病程，在严重程度和持续时间方面都可能会加剧。作为细胞因子的一个亚家族，趋化因子可作为多种细胞（包括免疫细胞）的化学引诱剂。CXCL12是CXC亚家族的重要成员，已在造血系统中得到广泛研究。在外周免疫系统中，CXCL12/CXCR4具有多种功能。CXCL12是淋巴细胞和单核细胞的高效化学引诱剂，但不是中性粒细胞的。CXCL12存在于MS患者及其他炎症性神经系统疾病患者的脑脊液（CSF）中。本研究的目的是总结关于CXCL12与MS之间关系的最新研究结果。
