Corsini Elena, Gaviani Paola, Chiapparini Luisa, Lazzaroni Monica, Ciusani Emilio, Bisogno Raffaele, Silvani Antonio, Salmaggi Andrea, Bernardi Gaetano
Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
Unit of Neurooncology, Department of Clinical Neurosciences, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
J Neuroimmunol. 2016 Jan 15;290:119-22. doi: 10.1016/j.jneuroim.2015.11.016. Epub 2015 Nov 22.
Paraneoplastic neurological syndromes (PNSs) are a group of immune-mediated neurological disorders occurring in patients with systemic cancers which are associated with the presence of anti-neuronal antibodies. In this retrospective study, serum and cerebrospinal fluid of 489 patients were analyzed for the presence of well characterized onconeural antibodies. The 18 PNS patients positive for onconeural antibodies were reanalyzed to evaluate possible intrathecal synthesis. Intrathecal synthesis of onconeural antibodies, was detected in 10/15 patients affected by PNSs involving the CNS and in 1/3 cases with peripheral syndromes. Our data confirm that onconeural antibodies are produced within the CNS in most PNS patients. Evaluation of intrathecal synthesis of onconeural antibodies on a larger cohort of PNS patients and the correlation with disease course might elucidate whether this marker has a value in predicting the prognosis of the neurological disease.
副肿瘤性神经系统综合征（PNSs）是一组发生在患有系统性癌症患者中的免疫介导性神经系统疾病，与抗神经元抗体的存在有关。在这项回顾性研究中，对489例患者的血清和脑脊液进行了分析，以检测特征明确的肿瘤神经抗体的存在。对18例肿瘤神经抗体呈阳性的PNS患者进行了重新分析，以评估可能的鞘内合成情况。在15例累及中枢神经系统的PNS患者中有10例检测到肿瘤神经抗体的鞘内合成，在外周综合征患者中有1/3的病例检测到。我们的数据证实，大多数PNS患者的中枢神经系统内会产生肿瘤神经抗体。对更大队列的PNS患者进行肿瘤神经抗体鞘内合成的评估以及与病程的相关性分析，可能会阐明该标志物是否对预测神经疾病的预后有价值。
