Hong Baoan, Chen Guowei, Zhao Yuan, Du Xin, Yang Yong, Zhang Xiaodong, Xing Nianzeng, Zhang Ning
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Department of Urology, Peking University, School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China, Email:
Zhonghua Yi Xue Za Zhi. 2015 Aug 25;95(32):2644-6.
To observe the ablation zone and characteristics of microwave ablation with different power and time in the model of porcine kidneys in vitro.
2 450 MHz water circulative-cooling microwave needles were used, and the length of the anterior pole was 1.10 cm. The independent variables were power (50-70 W), time (240-600 s) and ablated with different combinations. The ablation shape, zone and pathological characteristics were observed.
The effective ablation shape was similar to a chestnut and the ablation zone enlarged with the increasing of power and time. When combined with 50 W/480 s, 60 W/300 s, 70 W/240 s, the largest transverse-diameter of the ablated tissue was close to 3.00 cm and the length-diameter was about 3.30 cm. The pathological characteristics indicated that renal tissues of carbonization zone were thoroughly necrotic.Coagulative necrosis was observed in coagulation area, though there were residual profile of glomerulus, renal tubular and vessels, they had lost activity. Most of the tissues in transition zone were normal, however, some cells were swelling because of thermal damage.
Microwave ablation is an emerging thermal therapy which can be safely, effectively used in the treatment of renal tumors that are smaller than 3 cm.
在体外猪肾模型中观察不同功率和时间的微波消融的消融区及特点。
使用2根2 450 MHz水循环冷却微波针，针的前极长度为1.10 cm。自变量为功率（50 - 70 W）、时间（240 - 600 s），采用不同组合进行消融。观察消融形状、区域及病理特征。
有效消融形状类似栗子，消融区随功率和时间增加而扩大。当采用50 W/480 s、60 W/300 s、70 W/240 s组合时，消融组织的最大横径接近3.00 cm，纵径约为3.30 cm。病理特征显示，碳化区肾组织完全坏死。凝固区可见凝固性坏死，虽有肾小球、肾小管及血管的残留轮廓，但已失去活性。过渡区大部分组织正常，不过部分细胞因热损伤而肿胀。
微波消融是一种新兴的热疗方法，可安全、有效地用于治疗小于3 cm的肾肿瘤。
