Nakano S, Kawashima Y, Komatsu S, Sakai K, Eguchi S, Aosaki M, Misaki T, Ohara K, Tokunaga K
Nihon Kyobu Geka Gakkai Zasshi. 1989 Mar;37(3):423-30.
A total of 1281 patients (594 aortic and 687 mitral) received 734 mechanical valves (320 Björk-Shiley, 283 SJM and 131 Omniscience) and 547 biological (259 ionescu-Shiley, 227 Hancock, and 61 Carpentier-Edwards) were analyzed for postoperative valve dysfunction and thromboembolism. The actuarial survival rates (free from late cardiac deaths and valve-related deaths) were 88.6% (11 years) for mechanical mitral and 86.0% (11 years) for biological mitral valves, and 91.7% (16 years) and 88.5% (12 years), for mechanical and biological aortic valves, respectively. There were no significant differences among these groups. Actuarial rates of freedom from valve-related events were 88.7% (11 years) and 51.7%, for mechanical and biological mitral valves, respectively. There was significant difference between the two types of valves in over 7 years after surgery. In contrast, there were no significant differences between mechanical and biological aortic valves. Actuarial rates of freedom from valve dysfunction were 97.6% (11 years) for mechanical and 56.5% (12 years) for biological mitral valves. The net 12 year results showed no significant differences between the two types of mitral prosthetic valves, but a significantly increased rate of valve dysfunction in the biological mitral valves compared with the mechanical in over 6 years of the study. Concerning AVR, there were no significant differences in the incidence of valve dysfunction between mechanical and biological aortic valves. Actuarial rates of freedom thromboembolism were 92.3% (11 years) and 93.8% (11 years) for mechanical and biological mitral valves, respectively. There were no significant differences between the two types of mitral prosthetic valves.(ABSTRACT TRUNCATED AT 250 WORDS)
共有1281例患者（594例主动脉瓣置换和687例二尖瓣置换）接受了734枚机械瓣膜（320枚Björk-Shiley、283枚SJM和131枚Omniscience）和547枚生物瓣膜（259枚ionescu-Shiley、227枚Hancock和61枚Carpentier-Edwards），对其术后瓣膜功能障碍和血栓栓塞情况进行了分析。二尖瓣机械瓣和生物瓣的精算生存率（无晚期心脏死亡和瓣膜相关死亡）分别为88.6%（11年）和86.0%（11年），主动脉瓣机械瓣和生物瓣分别为91.7%（16年）和88.5%（12年）。这些组间无显著差异。二尖瓣机械瓣和生物瓣免于瓣膜相关事件的精算率分别为88.7%（11年）和51.7%。术后7年以上，两种瓣膜类型之间存在显著差异。相比之下，主动脉瓣机械瓣和生物瓣之间无显著差异。二尖瓣机械瓣免于瓣膜功能障碍的精算率为97.6%（11年），生物瓣为56.5%（12年）。12年的净结果显示，两种二尖瓣人工瓣膜之间无显著差异，但在研究的6年以上时间里，生物二尖瓣瓣膜功能障碍的发生率与机械瓣相比显著增加。关于主动脉瓣置换，主动脉瓣机械瓣和生物瓣之间瓣膜功能障碍的发生率无显著差异。二尖瓣机械瓣和生物瓣免于血栓栓塞的精算率分别为92.3%（11年）和93.8%（11年）。两种二尖瓣人工瓣膜之间无显著差异。（摘要截短于250字）
