Mena Nannig Patricia, Cubillos Celis M Paz, Toro Jara Claudia, Zuñiga Vergara Carlos
Servicio de Recién Nacidos, CA Dr. Sótero del Río, Santiago, Chile; Departamento de Neonatología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Servicio de Recién Nacidos, CA Dr. Sótero del Río, Santiago, Chile; Programa de Beca de Neonatología, Universidad de Chile, Santiago, Chile.
Rev Chil Pediatr. 2016 Jul-Aug;87(4):250-4. doi: 10.1016/j.rchipe.2015.11.002. Epub 2015 Dec 19.
The use of greater amounts of protein and energy during the first week of life is associated with hypophosphataemia in extreme preterm babies. The lowest phosphorus levels are described in intrauterine growth restricted (IUGR) babies.
To describe biochemistry levels in cord blood plasma in extreme premature, adequate and small for gestational age babies (AGA/SGA) and their relationship with plasma calcium and phosphorus levels during the first week of life.
A descriptive clinical study was performed in the Neonatology Service at Hospital Dr. Sótero del Río during 2013 and 2014. A biochemical analysis of cord blood was performed on 43 premature babies, as well as plasma calcium and phosphorus levels during the first week. The adequacy for gestational age was obtained using Alarcón- Pittaluga growth curves. Statistical significance was P<.05.
Cholesterol, transaminases, albumin and creatinine levels were similar for both AGA and SGA babies. Levels of pH, phosphorus, calcium and alkaline phosphatase were significantly lower in SGA babies. Urea nitrogen, uric acid and triglycerides levels were higher in SGA. The analysis during the first week showed a strong reduction in phosphorus levels, as well as an increase in calcium levels in proportion to the decrease in phosphorus in the SGA sub- group.
Intrauterine malnutrition in preterm babies is expressed in the modulation of plasma levels of calcium, phosphorus, alkaline phosphatase, urea nitrogen, uric acid and triglycerides. During post-natal life, when nutritional intake begins, a decrease in phosphorus and an increase in calcium levels appear, consistent with insufficient phosphorus intake during this period.
出生后第一周摄入大量蛋白质和能量与极早产儿低磷血症有关。宫内生长受限（IUGR）婴儿的磷水平最低。
描述极早产儿、适于胎龄儿和小于胎龄儿（AGA/SGA）脐带血血浆中的生化指标水平，及其与出生后第一周血浆钙和磷水平的关系。
2013年至2014年在索特罗·德尔里奥医生医院新生儿科进行了一项描述性临床研究。对43例早产儿的脐带血进行生化分析，并检测出生后第一周的血浆钙和磷水平。使用阿拉孔-皮塔卢加生长曲线确定胎龄是否合适。统计学显著性为P<0.05。
AGA和SGA婴儿的胆固醇、转氨酶、白蛋白和肌酐水平相似。SGA婴儿的pH值、磷、钙和碱性磷酸酶水平显著较低。SGA婴儿的尿素氮、尿酸和甘油三酯水平较高。第一周的分析显示，SGA亚组中磷水平大幅下降，钙水平随磷的减少而升高。
早产儿宫内营养不良表现为血浆钙、磷、碱性磷酸酶、尿素氮、尿酸和甘油三酯水平的调节。出生后开始营养摄入时，磷水平下降，钙水平上升，这与该时期磷摄入不足一致。
