Hong Da Young, Lee Ji-Soo, Lee Hyeon Gyu
Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea.
Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea.
Int J Biol Macromol. 2016 Apr;85:9-15. doi: 10.1016/j.ijbiomac.2015.12.044. Epub 2015 Dec 19.
The aim of this study was to improve the solubility of lutein through the use of chitosan (CS)/poly-γ-glutamic acid (γ-PGA) nanoencapsulation. In terms of redispersibility, water-soluble chitosan (WsCS)/γ-PGA nanoparticles (NPs) were better than insoluble chitosan (InCS)/γ-PGA NPs. The lutein-loaded WsCS/γ-PGA NP has a spherical form with a size around 200nm and a narrow size distribution (PDI<0.1). Solubility measures showed that nanoencapsulation of lutein into WsCS/γ-PGA NPs resulted in a significant 12-fold higher solubility compared to that of non-nanoencapsulated lutein (p<0.05). The redispersibility index of the lutein-loaded NPs was 1.01, indicating that they were completely reconstituted into aqueous solution as same as original aqueous solution. These results suggest that WsCS/γ-PGA nanoencapsulation can be used to enhance the solubility of lutein and other poorly water-soluble compounds.
本研究的目的是通过使用壳聚糖（CS）/聚γ-谷氨酸（γ-PGA）纳米包封来提高叶黄素的溶解度。在再分散性方面，水溶性壳聚糖（WsCS）/γ-PGA纳米颗粒（NPs）优于不溶性壳聚糖（InCS）/γ-PGA NPs。负载叶黄素的WsCS/γ-PGA NP呈球形，尺寸约为200nm，粒径分布窄（PDI<0.1）。溶解度测定表明，与未纳米包封的叶黄素相比，将叶黄素纳米包封到WsCS/γ-PGA NPs中可使其溶解度显著提高12倍（p<0.05）。负载叶黄素的NPs的再分散指数为1.01，表明它们能与原始水溶液一样完全重新分散到水溶液中。这些结果表明，WsCS/γ-PGA纳米包封可用于提高叶黄素和其他水溶性差的化合物的溶解度。
