Gerontology Program and Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil.
Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil.
J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1281-8. doi: 10.1093/gerona/glv216. Epub 2015 Dec 28.
Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1.
我们的目的是通过一项横断面研究，调查生理水平的可溶性胰岛素样生长因子-1（IGF-1）是否与最年长人群的冠状动脉和颈动脉粥样硬化负担以及体能相关。该研究纳入了 100 名无既往心血管事件的社区居住者。IGF-1 与内中膜厚度、颈动脉斑块数量和行走速度呈线性相关。与中低 IGF-1 三分位组相比，IGF-1 三分位组较高者右侧和左侧内中膜厚度较小，且动脉粥样硬化斑块减少。此外，IGF-1 三分位组较高者行走速度较快。另一方面，IGF-1 与冠状动脉钙化评分之间存在非线性关系，IGF-1 中三分位组与最低的钙化评分相关，而循环 IGF-1 水平较低的参与者显示出更高频率的高危形态斑块。总之，我们的报告支持在携带中等到更高血清 IGF-1 水平的最年长人群中存在一种与地域相关的、抗动脉粥样硬化表型。
