Paula Roberta S, Souza Vinícius C, Machado-Silva Wilcelly, Almeida Bruno Ratier S, Daros Andersen C, Gomes Lucy, Ferreira Aparecido P, Brito Ciro J, Córdova Cláudio, Moraes Clayton F, Nóbrega Otávio T
Universidade de Brasília (UnB), Brasília/DF, Brazil.
Centro Universitário de Brasília (UNICEUB), Brasília/DF, Brazil.
Clinics (Sao Paulo). 2016 Dec 1;71(12):725-732. doi: 10.6061/clinics/2016(12)09.
: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.
: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).
: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context.
: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
在全球范围内，血管疾病导致的死亡人数极高，因此仍需要可靠的重大事件标志物。当前的横断面研究调查了Klotho单倍型和Klotho血清水平与经典危险因素及血管事件临床病史之间的关联。
对168名老年人进行了临床、人体测量、生化和营养评估，并辅以基因分型（rs9536314和rs9527025）以及血清Klotho检测（酶联免疫吸附测定）。
Klotho水平和单倍型与血管事件的大多数经典危险因素均无关联，包括C反应蛋白和同型半胱氨酸等标志物。通过相关性分析（p = 0.006）和方差分析（p < 0.001），仅发现Klotho水平与既往心肌梗死的发生之间存在正相关，且这些关联与背景无关。
我们的结果表明，有心肌梗死临床病史的个体血清Klotho水平较高，但有冠状动脉疾病或中风病史的个体则不然。Klotho单倍型与本文研究的变量均无关联。
