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血压正常受试者盐敏感性测试的可靠性

Reliability of salt-sensitivity testing in normotensive subjects.

作者信息

Sharma A M, Schattenfroh S, Kribben A, Distler A

机构信息

Abteilung für Allgemeine Innere Medizin und Nephrologie, Universitätsklinikum Steglitz, Freie Universität Berlin.

出版信息

Klin Wochenschr. 1989 Jun 15;67(12):632-4. doi: 10.1007/BF01718145.

DOI:10.1007/BF01718145
PMID:2671475
Abstract

We examined the reliability of dietary salt-sensitivity testing by repeatedly studying the effects of a high (220 mmol/day) and low (20 mmol/day) salt diet in 15 normotensive subjects. Reliability of classification of salt-sensitivity as described by the kappa statistic was 0.87 implying an almost perfect strength of agreement between the two parts of the study. Whereas only 20% of the subjects with negative familial histories of hypertension were salt-sensitive, this was the case with 68% of the subjects with positive familial histories. Our results show that salt-sensitivity can be reliably tested in normotensive subjects and that it is related to a familial history of hypertension.

摘要

我们通过反复研究高盐饮食(220毫摩尔/天)和低盐饮食(20毫摩尔/天)对15名血压正常受试者的影响,检验了膳食盐敏感性测试的可靠性。用kappa统计量描述的盐敏感性分类可靠性为0.87,这意味着该研究的两部分之间存在几乎完美的一致性。虽然高血压家族史阴性的受试者中只有20%对盐敏感,但高血压家族史阳性的受试者中这一比例为68%。我们的结果表明,盐敏感性在血压正常的受试者中可以得到可靠的检测,并且它与高血压家族史有关。

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1
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2
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Pathophysiology and genetics of salt-sensitive hypertension.盐敏感性高血压的病理生理学与遗传学
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