Luft F C, Miller J Z, Weinberger M H, Grim C E, Daugherty S A, Christian J C
Klin Wochenschr. 1987 Feb 2;65(3):101-9. doi: 10.1007/BF01728599.
To examine the effect of genetic variance on blood pressure, sodium homeostasis, and its regulatory determinants, we studied 37 pairs of monozygotic twins and 18 pairs of dizygotic twins under conditions of volume expansion and contraction. We found that, in addition to blood pressure and body size, sodium excretion in response to provocative maneuvers, glomerular filtration rate, the renin-angiotensin system, and the sympathetic nervous system are influenced by genetic variance. To elucidate the interaction of genetic factors and an environmental influence, namely, salt intake, we restricted dietary sodium in 44 families of twin children. In addition to a modest decrease in blood pressure, we found heterogeneous responses in blood pressure indicative of sodium sensitivity and resistance which were normally distributed. Strong parent-offspring resemblances were found in baseline blood pressures which persisted when adjustments were made for age and weight. Further, mother-offspring resemblances were observed in the change in blood pressure with sodium restriction. We conclude that the control of sodium homeostasis is heritable and that the change in blood pressure with sodium restriction is familial as well. These data speak to the interaction between the genetic susceptibility to hypertension and environmental influences which may result in its expression.
为研究基因变异对血压、钠稳态及其调节决定因素的影响，我们在容量扩张和收缩条件下研究了37对同卵双胞胎和18对异卵双胞胎。我们发现，除血压和体型外，激发试验后的钠排泄、肾小球滤过率、肾素 - 血管紧张素系统和交感神经系统均受基因变异影响。为阐明基因因素与环境影响（即盐摄入）的相互作用，我们对44个双胞胎儿童家庭的饮食钠进行了限制。除血压适度下降外，我们发现血压存在异质性反应，表明钠敏感性和耐受性呈正态分布。在基线血压中发现了强烈的亲子相似性，在对年龄和体重进行调整后这种相似性依然存在。此外，在钠限制时血压变化中观察到了母婴相似性。我们得出结论，钠稳态的控制具有遗传性，钠限制时血压的变化也具有家族性。这些数据表明高血压的遗传易感性与环境影响之间的相互作用可能导致其表现。
