Ng Chong Guan, Mohamed Salina, See Mee Hoong, Harun Faizah, Dahlui Maznah, Sulaiman Ahmad Hatim, Zainal Nor Zuraida, Taib Nur Aishah
Department of Psychological Medicine, Faculty of Medicine, University Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia.
Department of Psychiatry, Faculty of Medicine, Universiti Teknologi MARA, Kuala Lumpur, Malaysia.
Health Qual Life Outcomes. 2015 Dec 30;13:205. doi: 10.1186/s12955-015-0401-7.
Depression and anxiety are common psychiatric morbidity among breast cancer patient. There is a lack of study examining the correlation between depression, anxiety and quality of life (QoL) with perceived social support (PSS) among breast cancer patients. This study aims to study the level of depression, anxiety, QoL and PSS among Malaysian breast cancer women over a period of 12 months and their associations at baseline, 6 and 12 months.
It is a 12 months prospective cohort study. Two hundred and twenty one female patients were included in the study. They were assessed at the time of diagnosis, 6 months and 12 month using Hospital Anxiety and Depression Scale (HADS), Quality-of-Life Questionnaire (QLQ-C30), Version 3.0 of the EORTC Study Group and Multidimensional Scale of Perceived Social Support (MSPSS). The information of age, ethnicity, types of treatment, and staging of cancer were collected.
The HADS anxiety and depression subscales scores of the subjects were relatively low. The level of anxiety reduced significantly at 6 and 12 months (Baseline - 6 months, p = 0.002; Baseline - 12 months, p < 0.001). There were no changes in the level of depression over the study period. The global status of QoL and MSPSS scores were relatively high. Correlation between the global status of QoL and MSPSS for the study subjects was positive (Spearman's rho = 0.31-0.36). Global status of QoL and MSPSS scores were negatively correlated with anxiety and depression.
Malaysian breast cancer women had relatively better QoL with lower level of anxiety and depression. Perceived social support was an important factor for better QoL and low level of psychological distress. It reflects the importance of attention on activities that enhance and maintain the social support system for breast cancer patients.
抑郁和焦虑是乳腺癌患者常见的精神疾病。目前缺乏研究探讨乳腺癌患者的抑郁、焦虑与生活质量（QoL）以及感知社会支持（PSS）之间的相关性。本研究旨在调查马来西亚乳腺癌女性在12个月期间的抑郁、焦虑、生活质量和感知社会支持水平，以及它们在基线、6个月和12个月时的关联。
这是一项为期12个月的前瞻性队列研究。221名女性患者纳入研究。在诊断时、6个月和12个月时，使用医院焦虑抑郁量表（HADS）、生活质量问卷（QLQ-C30）（欧洲癌症研究与治疗组织研究组第3.0版）和多维感知社会支持量表（MSPSS）对她们进行评估。收集年龄、种族、治疗类型和癌症分期等信息。
受试者的HADS焦虑和抑郁分量表得分相对较低。焦虑水平在6个月和12个月时显著降低（基线-6个月，p = 0.002；基线-12个月，p < 0.001）。在研究期间，抑郁水平没有变化。生活质量的总体状况和MSPSS得分相对较高。研究对象的生活质量总体状况与MSPSS之间呈正相关（斯皮尔曼等级相关系数=0.31-0.36）。生活质量总体状况和MSPSS得分与焦虑和抑郁呈负相关。
马来西亚乳腺癌女性的生活质量相对较好，焦虑和抑郁水平较低。感知社会支持是生活质量提高和心理困扰水平降低的重要因素。这反映了关注增强和维持乳腺癌患者社会支持系统活动的重要性。
