Stolley Melinda R, Sharp Lisa K, Fantuzzi Giamila, Arroyo Claudia, Sheean Patricia, Schiffer Linda, Campbell Richard, Gerber Ben
Cancer Center and Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226-3548, USA.
Institute for Health Research and Policy, University of Illinois at Chicago (UIC), Chicago, IL, USA.
BMC Cancer. 2015 Dec 29;15:1018. doi: 10.1186/s12885-015-2004-4.
Breast cancer survival rates are significantly lower among African-American women compared to white women. In addition, African-American women with breast cancer are more likely than white women to die from co-morbid conditions. Obesity is common among African-American women, and it contributes to breast cancer progression and the development and exacerbation of many weight-related conditions. Intervening upon obesity may decrease breast cancer and all-cause mortality among African-American breast cancer survivors.
METHODS/DESIGN: Moving Forward is a weight loss intervention being evaluated in a randomized trial with a projected sample of 240 African American breast cancer survivors. Outcomes include body mass index, body composition, waist:hip ratio, and behavioral, psychosocial and physiological measures. Survivors are randomized to either a 6-month guided weight loss intervention that involves twice weekly classes and text messaging or a self-guided weight loss intervention based on the same materials offered in the guided program. The guided intervention is being conducted in partnership with the Chicago Park District at park facilities in predominantly African-American neighborhoods in Chicago. Recruitment strategies include direct contact to women identified in hospital cancer registries, as well as community-based efforts. Data collection occurs at baseline, post-intervention (6 months) and at a 12-month follow-up.
This study evaluates a community-based, guided lifestyle intervention designed to improve the health of African-American breast cancer survivors. Few studies have addressed behavioral interventions in this high-risk population. If successful, the intervention may help reduce the risk for breast cancer recurrence, secondary cancers, and co-morbid conditions, as well as improve quality of life.
U.S. Clinicaltrials.gov number: NCT02482506, April 2015.
与白人女性相比，非裔美国女性的乳腺癌生存率显著较低。此外，患有乳腺癌的非裔美国女性比白人女性更有可能死于合并症。肥胖在非裔美国女性中很常见，它会促进乳腺癌的进展以及许多与体重相关疾病的发生和恶化。对肥胖进行干预可能会降低非裔美国乳腺癌幸存者患乳腺癌和全因死亡的风险。
方法/设计：“向前迈进”是一项正在进行的减肥干预措施，正在一项随机试验中进行评估，预计样本为240名非裔美国乳腺癌幸存者。结果包括体重指数、身体成分、腰臀比以及行为、心理社会和生理指标。幸存者被随机分为两组，一组接受为期6个月的指导性减肥干预，包括每周两次课程和短信提醒，另一组接受基于指导性项目提供的相同材料的自我指导性减肥干预。指导性干预是与芝加哥公园区合作，在芝加哥主要为非裔美国人社区的公园设施中进行的。招募策略包括直接联系医院癌症登记处确定的女性，以及基于社区的努力。数据收集在基线、干预后（6个月）和12个月随访时进行。
本研究评估了一项基于社区的、指导性的生活方式干预措施，旨在改善非裔美国乳腺癌幸存者的健康状况。很少有研究针对这一高风险人群的行为干预。如果成功，该干预措施可能有助于降低乳腺癌复发、继发性癌症和合并症的风险，以及提高生活质量。
美国Clinicaltrials.gov编号：NCT02482506，2015年4月。
