Ghazal Abdullatef, Roghani Farshad, Sadeghi Masoumeh, Amra Babak, Kermani-Alghoraishi Mohammad
Resident, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Associate Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2015 Sep;11(5):275-80.
Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep-related disorder that is associated with increased risk of hypertension (HTN) and coronary heart disease. This study aimed to evaluate the correlation between the OSAS and coronary artery disease (CAD) severity.
The cross-sectional study was conducted from September 2012 to December 2013. We enrolled 127 patients with chronic stable angina who were referred for coronary angiographic studies in Shahid Chamran and Nour Hospitals in Isfahan, Iran. The Berlin questionnaire (BQ) was used for estimate the probability of OSAS in patients as a low or high probability. Demographic characteristics and metabolic risk factors including diabetes mellitus, HTN, obesity, and smoking also were recorded. The severity of CAD was assessed and compared based on the Gensini score with Mann-Whitney U statistical test. Independent t-test for continuous variables and chi-square test for categorical variables were used.
Totally, 65.4% of subjects were considered as high and 34.6% as low probability for OSAS, which 81.1% of them had CAD. There was a significant difference between body mass index, systolic blood pressure, diastolic blood pressure, and ischemic heart disease drug consumption with OSAS probability (P < 0.0500). CAD was accompanied by OSAS significantly (P = 0.0260). The Gensini score was significantly higher in patients with high OSAS probability (100.4 ± 69.1 vs. 65.3 ± 68.9; P = 0.0030). OSAS also increase odds of CAD based on regression analysis (odds ratio, 95% confidence interval = 2.7).
This study indicates that more severe CAD is associated with high OSAS probability identified by BQ.
阻塞性睡眠呼吸暂停综合征（OSAS）是一种高度流行的与睡眠相关的疾病，与高血压（HTN）和冠心病风险增加相关。本研究旨在评估OSAS与冠状动脉疾病（CAD）严重程度之间的相关性。
横断面研究于2012年9月至2013年12月进行。我们纳入了127例慢性稳定型心绞痛患者，这些患者被转诊至伊朗伊斯法罕的沙希德·查姆兰医院和努尔医院进行冠状动脉造影研究。使用柏林问卷（BQ）评估患者发生OSAS的概率为低或高。还记录了人口统计学特征和代谢危险因素，包括糖尿病、HTN、肥胖和吸烟。基于Gensini评分评估并比较CAD的严重程度，采用曼-惠特尼U统计检验。连续变量采用独立t检验，分类变量采用卡方检验。
总体而言，65.4%的受试者被认为发生OSAS的概率高，34.6%的概率低，其中81.1%患有CAD。体重指数、收缩压、舒张压和缺血性心脏病药物消耗与OSAS概率之间存在显著差异（P<0.0500）。CAD与OSAS显著相关（P = 0.0260）。OSAS概率高的患者Gensini评分显著更高（100.4±69.1对65.3±68.9；P = 0.0030）。基于回归分析，OSAS也增加了CAD的发生几率（优势比，95%置信区间 = 2.7）。
本研究表明，更严重的CAD与BQ确定的高OSAS概率相关。
