Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Cad Saude Publica. 2012 Aug;28(8):1530-8. doi: 10.1590/s0102-311x2012000800011.
Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis ≥ 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.
阻塞性睡眠呼吸暂停（OSA）是冠心病的一个危险因素，但仍未得到充分诊断。我们研究了柏林问卷（BQ）识别的 OSA 是否与冠心病的风险相关。病例为因选择性冠状动脉造影而转诊的患者。病例分为有显著冠状动脉病变（心外膜冠状动脉狭窄≥50%）和无显著冠状动脉病变。对照组从基于人群的样本中选择。在 328 例病例中，有 135 例（41.2%）的 BQ 结果为阳性，而在 439 例对照中，有 151 例（34.4%）的 BQ 结果为阳性（p=0.03）。在多变量逻辑分析中，BQ 识别的 OSA 风险与至少 50%病变的病例中的冠心病独立相关（OR=1.53；95%CI：1.02-2.30；p=0.04）。BQ 识别的 OSA 风险在年龄在 40-59 岁的年轻患者（OR=1.76；95%CI：1.05-2.97；p=0.03）和女性（OR=3.56；95%CI：1.64-7.72；p=0.001）中更高。总之，BQ 识别的 OSA 大大增加了有显著冠状动脉病变的患者（通过血管造影显示）患冠心病的风险，尤其是在年轻个体和女性中。
