Kadow Brian T, Tyagi Pradeep, Chermansky Christopher J
Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.
Curr Bladder Dysfunct Rep. 2015 Dec 1;10(4):325-331. doi: 10.1007/s11884-015-0331-6. Epub 2015 Sep 15.
Detrusor underactivity (DU) is a poorly understood dysfunction of the lower urinary tract which arises from multiple etiologies. Symptoms of DU are non-specific, and a pressure-flow urodynamic study is necessary to differentiate DU from other conditions such as overactive bladder (OAB) or bladder outlet obstruction (BOO). The prevalence of DU ranges from 10-48%, and DU is most prevalent in elderly males. The pathophysiology underlying DU can be from both neurogenic and non-neurogenic causes. In this article, we review the neurogenic causes of detrusor underactivity, including diabetic bladder dysfunction, spinal cord injury, multiple sclerosis, Parkinson's disease, cerebrovascular accident, traumatic brain injury, and Fowler's syndrome. As knowledge about the underlying causes of DU advances, there have been several potential therapeutic approaches proposed to help those who suffer from this condition.
逼尿肌活动低下（DU）是一种病因多样、尚未被充分了解的下尿路功能障碍。DU的症状不具有特异性，需要进行压力-流率尿动力学检查以将DU与其他疾病（如膀胱过度活动症（OAB）或膀胱出口梗阻（BOO））区分开来。DU的患病率在10%至48%之间，且在老年男性中最为常见。DU的病理生理学可能源于神经源性和非神经源性原因。在本文中，我们回顾了逼尿肌活动低下的神经源性病因，包括糖尿病膀胱功能障碍、脊髓损伤、多发性硬化症、帕金森病、脑血管意外、创伤性脑损伤和福勒综合征。随着对DU潜在病因的认识不断深入，已经提出了几种潜在的治疗方法来帮助患有这种疾病的患者。
