一项确定马拉维布兰太尔市年轻成年马拉维人正常血液学指标的试点研究。
A pilot study to determine the normal haematological indices for young Malawian adults in Blantyre, Malawi.
作者信息
Chisale M R, Kumwenda P, Ngwira M, M'baya B, Chosamata B I, Mwapasa V
机构信息
Laboratory Section, Mzuzu Central Hospital, Mzuzu, Malawi.
Department of Biomedical Sciences, Mzuzu University, Mzuzu, Malawi.
出版信息
Malawi Med J. 2015 Sep;27(3):96-100. doi: 10.4314/mmj.v27i3.5.
BACKGROUND
Reference ranges for haematological and other laboratory tests in most African countries are based on populations in Europe and America and, because of environmental and genetic factors, these may not accurately reflect the normal reference ranges in African populations.
AIM
To determine the distribution of haematological parameters in healthy individuals residing in Blantyre, Malawi. We also examined the effect of sociodemographic and nutritional factors on the haematological variables.
METHODS
We conducted a proof-of-concept cross-sectional study, involving 105 healthy blood donors at Malawi Blood Transfusion Service in Blantyre. Eligible participants were HIV-negative males and females, aged 19 to 35 years, who did not have any evidence of acute or chronic illness, or blood-borne infection. We performed the haematological tests at the Malawi-Liverpool Wellcome Trust laboratory in Blantyre, and the screening tests at Malawi Blood Transfusion Service laboratories.
RESULTS
Out of 170 consenting healthy volunteers, haematological results were available for 105 participants. The proportions of results which were below the lower limit of the manufacturer's reference ranges were 35.2% (37/105) for haemoglobin, 15.2% (16/105) for neutrophils, 23.8% (25/105) for eosinophils, and 88.6 % (93/105) for basophils. The proportions of results that were above the upper limit of the manufacturer's reference ranges were 9.5% (10/105) for platelets and 12.4% (13/105) for monocytes. We also observed that the mean leucocyte and basophil counts were significantly higher in males than females (p = 0.042 and p = 0.015, respectively). There were no statistically significant differences in haematological results observed among different ethnic, age, and body mass index groups.
CONCLUSIONS
Over half of otherwise healthy study participants had at least one abnormal haematological result, using previously established foreign standards. More detailed studies are needed to establish locally relevant normal ranges for different age groups and other demographic characteristics of the Malawian population. This will lead to accurate interpretation of laboratory results.
背景
大多数非洲国家血液学及其他实验室检测的参考范围是基于欧美人群制定的，由于环境和遗传因素，这些范围可能无法准确反映非洲人群的正常参考范围。
目的
确定马拉维布兰太尔健康个体的血液学参数分布。我们还研究了社会人口统计学和营养因素对血液学变量的影响。
方法
我们开展了一项概念验证性横断面研究，纳入了布兰太尔马拉维输血服务中心的105名健康献血者。符合条件的参与者为19至35岁的HIV阴性男性和女性，无任何急性或慢性疾病或血源性感染的证据。我们在布兰太尔的马拉维-利物浦惠康信托实验室进行血液学检测，并在马拉维输血服务实验室进行筛查检测。
结果
在170名同意参与的健康志愿者中，105名参与者有血液学检测结果。血红蛋白低于制造商参考范围下限的结果比例为35.2%（37/105），中性粒细胞为15.2%（16/105），嗜酸性粒细胞为23.8%（25/105），嗜碱性粒细胞为88.6%（93/105）。血小板高于制造商参考范围上限的结果比例为9.5%（10/105），单核细胞为12.4%（13/105）。我们还观察到男性的平均白细胞和嗜碱性粒细胞计数显著高于女性（分别为p = 0.042和p = 0.015）。在不同种族、年龄和体重指数组之间观察到的血液学结果无统计学显著差异。
结论
按照先前制定的国外标准，超过一半的健康研究参与者至少有一项异常血液学结果。需要进行更详细的研究，以建立马拉维人群不同年龄组和其他人口特征的本地相关正常范围。这将有助于准确解读实验室结果。
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