Taffoni Clara, Pujol Nathalie
Center d'Immunologie de Marseille-Luminy; Aix Marseille Université UM2 ; Inserm; Marseille, France.
Tissue Barriers. 2015 Oct 5;3(4):e1078432. doi: 10.1080/21688370.2015.1078432. eCollection 2015 Oct-Dec.
The roundworm C. elegans has been successfully used for more than 50 y as a genetically tractable invertebrate model in diverse biological fields such as neurobiology, development and interactions. C. elegans feeds on bacteria and can be naturally infected by a wide range of microorganisms, including viruses, bacteria and fungi. Most of these pathogens infect C. elegans through its gut, but some have developed ways to infect the epidermis. In this review, we will mainly focus on epidermal innate immunity, in particular the signaling pathways and effectors activated upon wounding and fungal infection that serve to protect the host. We will discuss the parallels that exist between epidermal innate immune responses in nematodes and mammals.
秀丽隐杆线虫作为一种易于进行基因操作的无脊椎动物模型，在神经生物学、发育和相互作用等多种生物学领域已成功应用了50多年。秀丽隐杆线虫以细菌为食，可被包括病毒、细菌和真菌在内的多种微生物自然感染。这些病原体大多通过肠道感染秀丽隐杆线虫，但有些已进化出感染表皮的方式。在本综述中，我们将主要关注表皮天然免疫，特别是在受伤和真菌感染时激活的信号通路及效应因子，它们有助于保护宿主。我们将讨论线虫和哺乳动物表皮天然免疫反应之间存在的相似之处。
