Zhang Hang, Bai Ligai, Wei Zhen, Liu Sha, Liu Haiyan, Yan Hongyuan
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
Talanta. 2016;149:62-68. doi: 10.1016/j.talanta.2015.11.028. Epub 2015 Nov 14.
A polymer monolithic column was prepared in a stainless steel column (50×4.6mm i.d.) via atom transfer radical polymerization technique using triallyl isocyanurate and ionic liquid (1-allyl-3-methylimidazolium chloride) as co-monomers, ethylene dimethacrylate as cross linking agent, polyethylene glycol 200, 1,4-butanediol, and N, N- dimethylformamide as porogen system, CCl4 as initiator, and FeCl2 as catalyst. The optimized polymer columns were characterized by scanning electron microscope, nitrogen adsorption-desorption instrument, mercury intrusion porosimetry, infrared spectrometer, and thermogravimetric analysis technique. Respectively, all of these factors above could illustrate that the optimized columns had relative uniform macroporous structure and high thermal stability. A series of basic and acidic small molecules, isomers, and homologues were used to evaluate the performance of these monoliths and enhanced column efficiency was obtained.
采用原子转移自由基聚合技术，以三烯丙基异氰脲酸酯和离子液体（1-烯丙基-3-甲基咪唑氯盐）为共聚单体，二甲基丙烯酸乙二醇酯为交联剂，聚乙二醇200、1,4-丁二醇和N，N-二甲基甲酰胺为致孔剂体系，四氯化碳为引发剂，氯化亚铁为催化剂，在不锈钢柱（内径50×4.6mm）中制备了聚合物整体柱。通过扫描电子显微镜、氮吸附-脱附仪、压汞法、红外光谱仪和热重分析技术对优化后的聚合物柱进行了表征。上述所有因素分别表明，优化后的柱子具有相对均匀的大孔结构和高热稳定性。使用一系列碱性和酸性小分子、异构体和同系物来评估这些整体柱的性能，并获得了提高的柱效。
