流式细胞术评估隐球菌性脑膜炎患者脑脊液中的真菌负荷
Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis.
作者信息
Scriven James E, Graham Lisa M, Schutz Charlotte, Scriba Thomas J, Wilkinson Robert J, Boulware David R, Meintjes Graeme, Lalloo David G, Urban Britta C
机构信息
Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom Wellcome Trust Liverpool Glasgow Centre for Global Health Research, Liverpool, United Kingdom Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
出版信息
J Clin Microbiol. 2016 Mar;54(3):802-4. doi: 10.1128/JCM.03002-15. Epub 2015 Dec 30.
Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.
脑脊液中的真菌负荷是隐球菌性脑膜炎死亡率的重要决定因素，但由于进行定量培养所需时间较长，其在辅助临床决策中的应用受到了阻碍。在此，我们证明了流式细胞术作为一种新颖且快速的技术来解决这一问题的潜力。
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