Li Zhao-Xia, Gao Zhuang-Lei, Wang Jin-Na, Guo Qing-Hui
a The Second Hospital of Shandong University , Jinan , China.
b Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , China.
Fetal Pediatr Pathol. 2016;35(1):1-9. doi: 10.3109/15513815.2015.1122121. Epub 2015 Dec 31.
To examine the association between maternal coffee consumption during pregnancy and the occurrence of neural tube defects (NTDs) in offspring.
PubMed, Springer Link and Elsevier databases were searched up to August, 2014. Case-control and cohort studies published on the association between maternal coffee consumption during pregnancy and the occurrence of NTDs in offspring were included. Meta-analysis was applied to calculate the pooled effect estimates and their 95% confidence intervals (CIs) using a random-effects model.
A total of six case-control studies and one cohort study were included. The pooled effect estimate of maternal coffee consumption during pregnancy was 0.86 for total NTDs (95% CI: 0.51- 1.45) and 1.30 (95% CI: 0.67- 2.52) for NTDs subtype of spina bifida.
Our findings suggested that maternal coffee consumption during pregnancy was not significantly associated with the occurrence of total NTD or the spina bifida subtype of NTD.
探讨孕期母亲咖啡摄入量与子代神经管缺陷（NTDs）发生之间的关联。
检索截至2014年8月的PubMed、Springer Link和Elsevier数据库。纳入发表的关于孕期母亲咖啡摄入量与子代NTDs发生之间关联的病例对照研究和队列研究。采用随机效应模型进行Meta分析，以计算合并效应估计值及其95%置信区间（CIs）。
共纳入6项病例对照研究和1项队列研究。孕期母亲咖啡摄入量与总NTDs的合并效应估计值为0.86（95%CI：0.51 - 1.45），与脊柱裂NTDs亚型的合并效应估计值为1.30（95%CI：0.67 - 2.52）。
我们的研究结果表明，孕期母亲咖啡摄入量与总NTD或NTDs脊柱裂亚型的发生无显著关联。
