Fujiwara Kohta, Yasuda Miho, Ninomiya Toshiharu, Hata Jun, Hashimoto Sawako, Yoshitomi Takeshi, Kiyohara Yutaka, Ishibashi Tatsuro
Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Ophthalmology, Graduate School.
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7983-7. doi: 10.1167/iovs.15-16766.
To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population.
In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP.
The mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08).
The HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.
在日本普通人群中，研究胰岛素抵抗的替代指标——胰岛素抵抗稳态模型评估（HOMA-IR）与眼压（IOP）之间的关联。
2007年，共有3119名40岁及以上的日本社区居民接受了眼部检查，包括使用非接触眼压计测量眼压。其中，2254名居民参与了本研究。测量空腹血清葡萄糖和血浆胰岛素以确定HOMA-IR。使用线性回归模型评估HOMA-IR与IOP之间的关联，并对年龄和可能升高IOP的危险因素进行校正。
右眼平均眼压±标准差为13.7±2.7mmHg，左眼为13.6±2.7mmHg。在对年龄、性别、收缩压、糖尿病、总胆固醇、高密度脂蛋白胆固醇、体重指数、腰围、吸烟习惯、饮酒量和规律运动进行校正后，HOMA-IR水平升高与IOP升高显著相关（P<0.05）。在基于是否存在可能的混杂危险因素的亚组分析中，所有亚组之间均无异质性证据（异质性P>0.08）。
在校正混杂因素后，HOMA-IR与升高的IOP水平独立相关。
