Wu Jia, Liang Shu, Shapiro Linda, Tse Raymond
Cleft Palate Craniofac J. 2016 Nov;53(6):705-713. doi: 10.1597/15-220. Epub 2015 Dec 31.
The first part of this study validated an automated computer-based method of identifying the three-dimensional midfacial plane in children with unrepaired cleft lip. The purpose of this second part is to develop computer-based methods to quantify symmetry and to determine the correlation of these measures to clinical expectations.
A total of 35 infants with unrepaired unilateral cleft lip and 14 infant controls.
Six computer-based methods of quantifying symmetry were developed and applied to the three-dimensional images of infants with unilateral cleft lip before and after cleft lip repair and to those of controls.
Symmetry scores for cleft type, changes with surgery, and individual subjects ranked according to cleft severity were assessed.
Significant differences in symmetry scores were found between cleft types and found before and after surgery. Symmetry scores for infants with unilateral cleft lip approached those of controls after surgery, and there was a strong correlation with ranked cleft severity.
Our computer-based three-dimensional analysis of nasolabial symmetry correlated with clinical expectations. Automated processing made measurement convenient. Use of these measures may help to objectively measure cleft severity and treatment outcome.
本研究的第一部分验证了一种基于计算机的自动化方法，用于识别未修复唇裂患儿的三维面中平面。第二部分的目的是开发基于计算机的方法来量化对称性，并确定这些测量值与临床预期的相关性。
共有35例未修复单侧唇裂婴儿和14例婴儿对照。
开发了六种基于计算机的量化对称性的方法，并将其应用于单侧唇裂婴儿唇裂修复前后的三维图像以及对照的三维图像。
评估不同腭裂类型、手术前后变化以及根据腭裂严重程度排序的个体受试者的对称性评分。
不同腭裂类型之间以及手术前后的对称性评分存在显著差异。单侧唇裂婴儿术后的对称性评分接近对照组，且与腭裂严重程度排名密切相关。
我们基于计算机的鼻唇对称性三维分析与临床预期相关。自动化处理使测量变得方便。使用这些测量方法可能有助于客观地评估腭裂严重程度和治疗效果。
