Paraskevas Kosmas I, Mikhailidis Dimitri P, Veith Frank J, Spence J David
Department of Vascular Surgery, Southampton University Hospital, Southampton, United Kingdom
Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, United Kingdom.
Angiology. 2016 May;67(5):411-9. doi: 10.1177/0003319715624526. Epub 2015 Dec 31.
Implementation of best medical treatment (BMT) is the cornerstone of the management of patients with either asymptomatic or symptomatic carotid artery stenosis. We review the literature to define the components of BMT. Smoking cessation, maintaining a healthy body weight, moderate exercise, and a Mediterranean diet are essential lifestyle measures. Moderate alcohol consumption may also be beneficial but recommending it to patients may be hazardous if they consume too much. The importance of lifestyle measures is largely underestimated by both physicians and patients. Blood pressure and diabetes control, antiplatelet agents, and lipid-lowering treatment with statins/ezetimibe comprise the pharmacological components of BMT. Initiation of an intensive regimen of BMT is a sine qua non for patients with carotid artery stenosis whether or not they are offered or undergo an invasive revascularization procedure.
实施最佳药物治疗(BMT)是无症状或有症状颈动脉狭窄患者管理的基石。我们回顾文献以界定BMT的组成部分。戒烟、保持健康体重、适度运动和地中海饮食是必不可少的生活方式措施。适度饮酒可能也有益处,但如果患者饮酒过量,向他们推荐饮酒可能有害。医生和患者很大程度上都低估了生活方式措施的重要性。血压和糖尿病控制、抗血小板药物以及使用他汀类药物/依泽替米贝进行降脂治疗构成了BMT的药物组成部分。无论是否接受有创血管重建手术,启动强化的BMT方案对颈动脉狭窄患者而言都是必不可少的。