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硫芥暴露与非缺血性视网膜中央静脉阻塞

Sulfur Mustard Exposure and Non-Ischemic Central Retinal Vein Occlusion.

作者信息

Shoeibi Nasser, Balali-Mood Mahdi, Abrishami Mojtaba

机构信息

Retina Research Center, Department of Ophthalmology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; Eye Research Center, Department of Ophthalmology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; Department of Clinical Toxicology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran J Med Sci. 2016 Jan;41(1):59-63.

Abstract

A 41-year-old man was referred with a complaint of visual loss in his left eye and his best corrected visual acuity was 20/80. Slit lamp examination showed arborizing conjunctival vessels and dry eye. Fundus examination and fluorescein angiography revealed a non-ischemic central retinal vein occlusion. Cardiovascular, rheumatologic, and hematologic work up showed no abnormal findings. An ascertained history of exposure to sulfur mustard during the Iran-Iraq war was documented in his medical history. Four sessions of intravitreal bevacizumab injections were done as needed. After two-year follow-up, visual acuity in his left eye improved to 20/25 and macular edema was resolved without any need for further interventions. We conclude that sulfur mustard gas exposure may be considered as a predisposing factor for central retinal vein occlusion, as was found in our patient (an Iranian war veteran) by excluding all yet known etiologies and predisposing factors.

摘要

一名41岁男性因左眼视力丧失前来就诊,其最佳矫正视力为20/80。裂隙灯检查显示结膜血管呈树枝状分布及干眼。眼底检查和荧光素血管造影显示为非缺血性视网膜中央静脉阻塞。心血管、风湿和血液学检查未发现异常结果。其病史记录显示他在两伊战争期间有明确的接触芥子气史。根据需要进行了4次玻璃体内注射贝伐单抗治疗。经过两年的随访,其左眼视力提高到20/25,黄斑水肿消退,无需进一步干预。我们得出结论,芥子气暴露可能被视为视网膜中央静脉阻塞的一个诱发因素,就像我们的患者(一名伊朗退伍军人)那样,通过排除所有已知的病因和诱发因素后发现了这一关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1473/4691272/8efff88f6d83/IJMS-41-59-g001.jpg

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