Pan Zhenyu, Yang Guozi, Qu Limei, Yuan Tingting, Pang Xiaochuan, Wang Yongxiang, Shi Weiyan, Dong Lihua
Department of Radiotherapy, Norman Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Pathology, Norman Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Oncol Lett. 2015 Nov;10(5):2915-2918. doi: 10.3892/ol.2015.3643. Epub 2015 Aug 25.
The present study reports the case of a 53-year-old man with leptomeningeal metastasis from early glottic laryngeal cancer. The patient had been diagnosed with squamous cell carcinoma of the glottic larynx 9 years previously. The current symptoms included a recurring headache that had persisted for 1 month and vomiting for 1 week. A magnetic resonance imaging scan of the head revealed multiple enhancing lesions in the brain and multiple line-like enhancements in the brain fold. Computed tomography scans of the head, neck, chest and abdomen showed no nodular lesions. Cytological examination of the cerebral spinal fluid (CSF) revealed malignant cells with a scattered distribution pattern. The patient received intra-CSF methotrexate chemotherapy concurrent with whole-brain radiotherapy, which relieved the neurological symptoms. To the best of our knowledge, this is the first case of cytologically-confirmed LM from early glottic laryngeal cancer.
本研究报告了一例53岁男性，患有早期声门型喉癌的软脑膜转移。该患者9年前被诊断为声门型喉鳞状细胞癌。目前的症状包括持续1个月的反复头痛和持续1周的呕吐。头部磁共振成像扫描显示脑部有多个强化病灶，脑沟有多个线状强化。头部、颈部、胸部和腹部的计算机断层扫描未显示结节性病变。脑脊液（CSF）细胞学检查发现恶性细胞呈散在分布模式。患者接受了脑脊液内甲氨蝶呤化疗并同时进行全脑放疗，神经症状得到缓解。据我们所知，这是首例经细胞学确诊的早期声门型喉癌软脑膜转移病例。
