Montano Nicola, Rapisarda Alessandro, Pignotti Fabrizio, Gessi Marco
Department of Neurosurgery, Catholic University, Rome, Italy.
Department of Pathology, Catholic University, Rome, Italy.
Surg Neurol Int. 2018 Sep 4;9:179. doi: 10.4103/sni.sni_141_18. eCollection 2018.
Brain metastases from laryngeal squamous cell carcinoma (SCC) are rare, and there are no standardized treatments. Here we reported on a case of brain metastasis from laryngeal SCC and performed a literature review on these cases. Moreover, by plotting Kaplan-Meier curves, we carried out a survival analysis to provide an estimation of overall survival (OS) and to find possible prognostic factors.
A 65-year-old male was admitted to our department with a large left occipital lesion. Three years ago, the patient had undergone total laryngectomy with bilateral neck dissection with a diagnosis of a poor differentiated SCC. The occipital lesion was totally removed. A diagnosis of a brain metastasis from laryngeal SCC was made. The patient was submitted to adjuvant chemotherapy and radiation therapy. He is in good clinical conditions at 7-month follow-up with a still ongoing chemotherapy. From survival analysis, we have found that surgery and/or radiochemotherapy increase the OS of these patients compared with untreated cases. Moreover, Karnofsky performance status (KPS) score ≥70 and recursive partitioning analysis (RPA) classes I and II were associated with better OS in these patients.
Brain metastases from laryngeal SCC are rare. This is the first study in which a survival analysis of these cases has been performed. Surgery and/or radio-chemotherapy increase the survival of these patients compared with untreated cases. Moreover, KPS score and RPA class affect the outcome of these patients.
喉鳞状细胞癌（SCC）脑转移罕见，且尚无标准化治疗方案。在此，我们报告1例喉SCC脑转移病例，并对这些病例进行文献综述。此外，通过绘制Kaplan-Meier曲线，我们进行了生存分析，以评估总生存期（OS）并寻找可能的预后因素。
一名65岁男性因左侧枕叶巨大病变入住我科。3年前，该患者因诊断为低分化SCC接受了全喉切除术及双侧颈清扫术。枕叶病变被完全切除。诊断为喉SCC脑转移。该患者接受了辅助化疗和放疗。在7个月的随访中，他临床状况良好，化疗仍在进行。通过生存分析，我们发现与未治疗的病例相比，手术和/或放化疗可提高这些患者的OS。此外，卡诺夫斯基功能状态（KPS）评分≥70以及递归分区分析（RPA）I类和II类与这些患者更好的OS相关。
喉SCC脑转移罕见。这是首次对这些病例进行生存分析的研究。与未治疗的病例相比，手术和/或放化疗可提高这些患者的生存率。此外，KPS评分和RPA类别影响这些患者的预后。
