MTA2和Ki-67在肝细胞癌中的表达及其与预后的相关性。
Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis.
作者信息
Shi Wei, Hu Jiangfeng, Zhu Shizhang, Shen Xiaoying, Zhang Xiaoyan, Yang Changqing, Gao Hengjun, Zhang Hao
机构信息
Department of General Surgery, Huashan Hospital, Fudan University Shanghai 200040, China.
Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai 200065, China.
出版信息
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13083-9. eCollection 2015.
The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.
本研究旨在探讨MTA2、Ki-67与肝癌患者预后之间的关系。采用组织芯片和免疫组化法检测肝癌样本及相应癌旁样本中MTA2和Ki-67的表达。我们发现，肝癌组织中MTA2和Ki-67的表达均高于癌旁组织，且细胞核MTA2与Ki-67相关（P = 0.019）。此外，细胞核MTA2是肝癌患者远处转移的危险因素，Ki-67与组织学分级呈负相关（分别为P < 0.05，P < 0.01）。多因素Cox模型分析显示，Ki-67表达是肝癌患者的独立预后因素（P = 0.020）。这些结果表明，MTA2、Ki-67与肝癌预后之间可能存在密切关联。MTA2联合Ki-67可能用于预测肝癌患者的预后。
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