MTA2表达水平与结直肠癌之间的预后相关性
Prognostic correlation between MTA2 expression level and colorectal cancer.
作者信息
Ding Weijun, Hu Wei, Yang Haihua, Ying Ting, Tian Ye
机构信息
Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Department of Radiotherapy and Oncology, The Affiliated Taizhou Hospital of Wenzhou Medical University Taizhou 317000, China.
Department of Radiotherapy and Oncology, The Affiliated Taizhou Hospital of Wenzhou Medical University Taizhou 317000, China.
出版信息
Int J Clin Exp Pathol. 2015 Jun 1;8(6):7173-80. eCollection 2015.
OBJECTIVES
Association of MTA2 expression with presence, development, metastasis and prognosis of colorectal cancer (CRC) was investigated.
METHODS
90 CRC-related cases with follow-up information were made into tissue microarrays according to the paired principle of cancer tissues and the adjacent tissues. Subsequently, the expression of MAT2 was detected with immunohistochemical analysis and SPSS software was finally utilized to analyze the relationships between experimental data and clinical indicatives.
RESULTS
Expression of MTA2 in CRC tissues were notably higher than their adjacent tissues (P < 0.001) and showed significant positive correlation with tumor grade (r(2) > 0, P < 0.01). Moreover, survival analysis indicated that MTA2 expression in cancer tissues, serving as an independent correlation factor, was significantly correlated with poor prognosis (P = 0.004).
CONCLUSIONS
MTA2 is a crucial biomarker that is closely related with prognosis of CRC and also a potential molecular target for evaluating the prognosis and treatment of CRC.
目的
研究MTA2表达与结直肠癌（CRC）的发生、发展、转移及预后的关系。
方法
根据癌组织与癌旁组织配对原则，将90例有随访信息的CRC相关病例制成组织芯片。随后，采用免疫组化分析检测MAT2的表达，最后利用SPSS软件分析实验数据与临床指标之间的关系。
结果
CRC组织中MTA2的表达明显高于其癌旁组织（P < 0.001），且与肿瘤分级呈显著正相关（r(2)>0，P < 0.01）。此外，生存分析表明，癌组织中MTA2的表达作为一个独立的相关因素，与预后不良显著相关（P = 0.004）。
结论
MTA2是一个与CRC预后密切相关的关键生物标志物，也是评估CRC预后和治疗的潜在分子靶点。
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