Weiss H
Med. Klinik St. Marienkrankenhaus Ludwigshafen.
Ultraschall Med. 1989 Jun;10(3):147-51. doi: 10.1055/s-2007-1005981.
Tumour cells appear spontaneously in the blood of tumour patients. However, the formation of metastases depends not only on the number of tumour cells, but also to a large degree on the defence status of the patient. According to the experiments presented here, fine needle puncture can slightly increase tumour cell migration. Tumour cells are carried through the puncture channel into the bloodstream; case reports show that in some cases the number of tumour cells mobilised in this manner may be sufficient to induce a metastatic growth at the site of puncture. However, practically all reported cases concerned advanced tumour stages. The puncture metastasis did not exercise any influence on the course of the disease or on the prognosis. The incidence of metastases in the puncture channel after fine needle biopsy of tumours of various organs is between 0.003 and 0.005% and is hence low. Nevertheless, indication for fine needle puncture of malignant processes should be considered very critically. However, if the use of the puncture leads one to expect therapeutic consequences that are of relevance for the patient, the doctor should not hesitate to employ this method which has a high informative value.
肿瘤细胞会自发地出现在肿瘤患者的血液中。然而,转移灶的形成不仅取决于肿瘤细胞的数量,在很大程度上还取决于患者的防御状态。根据此处展示的实验,细针穿刺会轻微增加肿瘤细胞的迁移。肿瘤细胞通过穿刺通道进入血液循环;病例报告显示,在某些情况下,以这种方式动员的肿瘤细胞数量可能足以在穿刺部位诱发转移性生长。然而,几乎所有报告的病例都涉及晚期肿瘤阶段。穿刺转移对疾病进程或预后没有任何影响。对各种器官肿瘤进行细针活检后,穿刺通道中转移灶的发生率在0.003%至0.005%之间,因此发生率较低。尽管如此,对于恶性病变进行细针穿刺的指征应非常审慎地考虑。然而,如果穿刺的使用能带来对患者有意义的治疗效果,医生应毫不犹豫地采用这种具有高信息价值的方法。