Massocatto C L, Moreira N M, Muniz E, Pinge-Filho P, Rossi R M, Araújo E J de A, Sant'Ana D de M G
Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Brazil.
Department of Pathological Sciences, Universidade Estadual de Londrina, Londrina, Brazil.
Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12449.
The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the atrophy caused by the Trypanosoma cruzi infection. The mice were infected with 1300 trypomastigotes of Y strain T. cruzi intraperitoneally. Part of infected mice was treated with ASA from fifth to twelfth day after inoculation. Our data support the hypothesis that eicosanoids given during the acute phase of the chagasic infection may act as immunomodulators aiding the transition to and maintenance of the chronic phase of the disease. Besides, ASA treatment did not provoke alterations in the esophageal wall and the myenteric neurons in infected mice.
使用阿司匹林（ASA）对恰加斯病发病机制的影响尚不清楚。本研究评估了用ASA治疗恰加斯病对小鼠食管含氮能的肠肌间神经元群体和食管壁的影响。我们观察到，用ASA治疗恰加斯感染可保护食管肠肌间神经元免受克氏锥虫感染引起的萎缩。将小鼠腹腔注射1300个Y株克氏锥虫的锥鞭毛体进行感染。部分感染小鼠在接种后第5天至第12天用ASA治疗。我们的数据支持这样的假设，即在恰加斯感染急性期给予的类花生酸可能作为免疫调节剂，有助于疾病向慢性期转变并维持慢性期。此外，ASA治疗未引起感染小鼠食管壁和肠肌间神经元的改变。
